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RGS16 regulator of G protein signaling 16 [ Homo sapiens (human) ]

Gene ID: 6004, updated on 5-Mar-2024

Summary

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Official Symbol
RGS16provided by HGNC
Official Full Name
regulator of G protein signaling 16provided by HGNC
Primary source
HGNC:HGNC:9997
See related
Ensembl:ENSG00000143333 MIM:602514; AllianceGenome:HGNC:9997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGS-R; A28-RGS14; A28-RGS14P
Summary
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 20.2), lung (RPKM 3.6) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
1q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182598623..182604389, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (181958121..181963886, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182567758..182573524, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:182419119-182419726 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:182443692-182444891 Neighboring gene regulator of G protein signaling like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2198 Neighboring gene ribonuclease L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182584000-182584897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182584926-182585474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182585475-182586022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2205 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182612621-182613820 Neighboring gene regulator of G protein signaling 8 Neighboring gene long intergenic non-protein coding RNA 1688

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis. Zhu F, et al. Eur J Gastroenterol Hepatol, 2022 Oct 1. PMID 35830366, Free PMC Article
  2. RGS16 promotes glioma progression and serves as a prognostic factor. Huang R, et al. CNS Neurosci Ther, 2020 Aug. PMID 32319728, Free PMC Article
  3. RGS16 restricts the pro-inflammatory response of monocytes. Suurväli J, et al. Scand J Immunol, 2015 Jan. PMID 25366993
  4. RGS16 is a marker for prognosis in colorectal cancer. Miyoshi N, et al. Ann Surg Oncol, 2009 Dec. PMID 19760045
  5. RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. Liang G, et al. J Biol Chem, 2009 Aug 7. PMID 19509421, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration.
    Title: RGS16 regulates Hippo-YAP activity to promote esophageal cancer cell proliferation and migration.
  2. RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.
    Title: RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway.
  3. Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10.
    Title: Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10.
  4. Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis.
    Title: Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis.
  5. RGS16 promotes glioma progression and serves as a prognostic factor.
    Title: RGS16 promotes glioma progression and serves as a prognostic factor.
  6. Data show that bothregulator of G protein signaling (RGS16 and RGS18) inhibit protease-activated receptor 2 (PAR2)/G-protein, Gi-Go subunits (Galphai/o) -mediated signaling.
    Title: The regulators of G protein signaling RGS16 and RGS18 inhibit protease-activated receptor 2/Gi/o signaling through distinct interactions with Gα in live cells.
  7. Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW]
    Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
  8. The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16.
    Title: miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis.
  9. suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
    Title: The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.
  10. these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
    Title: RGS16 restricts the pro-inflammatory response of monocytes.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in visual perception TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 16
Names
hRGS-r
regulator of G-protein signalling 16
retinal-specific RGS
retinally abundant regulator of G-protein signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002928.4 → NP_002919.3  regulator of G-protein signaling 16

    See identical proteins and their annotated locations for NP_002919.3

    Status: REVIEWED

    Source sequence(s)
    AL353778, BC006243, DA060276, DC349953
    Consensus CDS
    CCDS1348.1
    UniProtKB/Swiss-Prot
    B2R4M4, O15492, Q5VYN9, Q99701
    Related
    ENSP00000356529.5, ENST00000367558.6
    Conserved Domains (1) summary
    cd08710
    Location:66 → 179
    RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    182598623..182604389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448796.1 → XP_024304564.1  regulator of G-protein signaling 16 isoform X1

    Conserved Domains (1) summary
    cd08710
    Location:65 → 178
    RGS_RGS16; Regulator of G protein signaling (RGS) domain found in the RGS16 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    181958121..181963886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338046.1 → XP_054194021.1  regulator of G-protein signaling 16 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15492.2 GenPept UniProtKB/Swiss-Prot:O15492

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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