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Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 59126, updated on 16-Apr-2024

Summary

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Official Symbol
Nek6provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 6provided by MGI
Primary source
MGI:MGI:1891638
See related
Ensembl:ENSMUSG00000026749 AllianceGenome:MGI:1891638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300007C09Rik
Summary
Predicted to enable several functions, including ATP binding activity; enzyme binding activity; and kinesin binding activity. Predicted to be involved in chromosome segregation; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to act upstream of or within apoptotic process; cell division; and phosphorylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 28.6), small intestine adult (RPKM 28.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Nek6 in Genome Data Viewer
Location:
2 B; 2 24.41 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38314052..38477502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38483863..38587490)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 27197 Neighboring gene STARR-seq mESC enhancer starr_04322 Neighboring gene LIM homeobox protein 2 Neighboring gene predicted gene 13584 Neighboring gene STARR-seq mESC enhancer starr_04324 Neighboring gene predicted gene, 39799 Neighboring gene predicted gene, 25081 Neighboring gene STARR-positive B cell enhancer ABC_E4444 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04330 Neighboring gene predicted gene, 35808 Neighboring gene STARR-seq mESC enhancer starr_04333 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38471578-38471879 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene STARR-positive B cell enhancer ABC_E4445 Neighboring gene STARR-seq mESC enhancer starr_04335 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:38499471-38499654 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04336 Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6. Jeltema D, et al. J Immunol, 2022 Apr 15. PMID 35354613, Free PMC Article
  2. Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. Bian Z, et al. PLoS One, 2014. PMID 24763737, Free PMC Article
  3. Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. Jeon YJ, et al. J Biol Chem, 2010 Sep 3. PMID 20595392, Free PMC Article
  4. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling. Fu B, et al. mBio, 2020 Jun 2. PMID 32487755, Free PMC Article
  5. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Hashimoto Y, et al. Biochem Biophys Res Commun, 2002 May 3. PMID 12054534

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
    Title: A Single Amino Acid Residue Defines the Difference in NLRP3 Inflammasome Activation between NEK7 and NEK6.
  2. MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
    Title: MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling.
  3. NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
    Title: Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
  4. During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
    Title: The related murine kinases, Nek6 and Nek7, display distinct patterns of expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek6
Names
NIMA-related expressed kinase 6
never in mitosis A-related kinase 6
nimA-related protein kinase 6
NP_001153103.1
NP_067619.1
XP_006498272.1
XP_006498273.1
XP_030107782.1
XP_030107783.1
XP_030107784.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159631.1 → NP_001153103.1  serine/threonine-protein kinase Nek6

    See identical proteins and their annotated locations for NP_001153103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK086700, BY205493
    Consensus CDS
    CCDS16009.1
    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Related
    ENSMUSP00000108516.2, ENSMUST00000112895.8
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  2. NM_021606.3 → NP_067619.1  serine/threonine-protein kinase Nek6

    See identical proteins and their annotated locations for NP_067619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF218847, AK086700
    Consensus CDS
    CCDS16009.1
    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Related
    ENSMUSP00000049723.4, ENSMUST00000054234.10
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    38314052..38477502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251924.2 → XP_030107784.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  2. XM_030251922.2 → XP_030107782.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  3. XM_030251923.2 → XP_030107783.1  serine/threonine-protein kinase Nek6 isoform X2

    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  4. XM_006498210.5 → XP_006498273.1  serine/threonine-protein kinase Nek6 isoform X2

    See identical proteins and their annotated locations for XP_006498273.1

    UniProtKB/Swiss-Prot
    Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
    UniProtKB/TrEMBL
    A2ATN9
    Conserved Domains (1) summary
    cd08228
    Location:42 → 309
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

  5. XM_006498209.5 → XP_006498272.1  serine/threonine-protein kinase Nek6 isoform X1

    Conserved Domains (1) summary
    cd08228
    Location:87 → 354
    STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES70.1 GenPept UniProtKB/Swiss-Prot:Q9ES70

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