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Midn midnolin [ Mus musculus (house mouse) ]

Gene ID: 59090, updated on 22-Apr-2024

Summary

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Official Symbol
Midnprovided by MGI
Official Full Name
midnolinprovided by MGI
Primary source
MGI:MGI:1890222
See related
Ensembl:ENSMUSG00000035621 AllianceGenome:MGI:1890222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3000003C15Rik
Summary
This gene encodes a protein that contains an ubiquitin-like domain. This protein may be involved in the regulation of brain development as inferred by its high expression level in the embryonic midbrain. This protein has been found to negatively regulate glucokinase activity and insulin secretion in pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in duodenum adult (RPKM 75.4), thymus adult (RPKM 75.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79984106..79994202)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80146005..80158368)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E576 Neighboring gene family with sequence similarity 174, member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. Kweon SM, et al. Am J Physiol Gastrointest Liver Physiol, 2023 Aug 1. PMID 37129245,
  2. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara M, et al. Gene, 2000 Aug 22. PMID 10974535
  3. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. Hofmeister-Brix A, et al. J Biol Chem, 2013 Dec 13. PMID 24187134, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Viable mutations of mouse midnolin suppress B cell malignancies.
    Title: Viable mutations of mouse midnolin suppress B cell malignancies.
  2. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
    Title: Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
  3. midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells
    Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
midnolin
Names
midbrain nucleolar protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305798.1 → NP_001292727.1  midnolin isoform 2

    See identical proteins and their annotated locations for NP_001292727.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, and 9 all encode the same isoform (2).
    Source sequence(s)
    AB036882, AI117487, AK164651
    UniProtKB/Swiss-Prot
    Q3TPJ7
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  2. NM_001305799.2 → NP_001292728.1  midnolin isoform 3

    See identical proteins and their annotated locations for NP_001292728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3 and 8 both encode the same isoform (3).
    Source sequence(s)
    AB036882, AC159999, AI117487, BM944891, BY168322
    UniProtKB/Swiss-Prot
    Q3TPJ7
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  3. NM_001347117.1 → NP_001334046.1  midnolin isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Variants 4, 6, and 7 all encode the same isoform (4).
    Source sequence(s)
    AB036882, AI117487, AK164324, AK164651
    Consensus CDS
    CCDS83727.1
    UniProtKB/Swiss-Prot
    Q3TPJ7, Q3U3X5, Q9JJJ6
    Related
    ENSMUSP00000097091.4, ENSMUST00000099492.10
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  4. NM_001388475.1 → NP_001375404.1  midnolin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC159999
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  5. NM_001388476.1 → NP_001375405.1  midnolin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC159999
    UniProtKB/Swiss-Prot
    Q3TPJ7, Q3U3X5, Q9JJJ6
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  6. NM_001388477.1 → NP_001375406.1  midnolin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC159999
    UniProtKB/Swiss-Prot
    Q3TPJ7, Q3U3X5, Q9JJJ6
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  7. NM_001388478.1 → NP_001375407.1  midnolin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC159999
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  8. NM_001429288.1 → NP_001416217.1  midnolin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC159999

  9. NM_001429289.1 → NP_001416218.1  midnolin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC159999

  10. NM_001429290.1 → NP_001416219.1  midnolin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC159999

  11. NM_001429291.1 → NP_001416220.1  midnolin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC159999

  12. NM_021565.2 → NP_067540.1  midnolin isoform 1

    See identical proteins and their annotated locations for NP_067540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB036882, AI117487, AK164324
    Consensus CDS
    CCDS24011.1
    UniProtKB/Swiss-Prot
    Q3TPJ7
    Related
    ENSMUSP00000046967.6, ENSMUST00000042057.12
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79984106..79994202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513913.4 → XP_006513976.1  midnolin isoform X1

    See identical proteins and their annotated locations for XP_006513976.1

    UniProtKB/Swiss-Prot
    Q3TPJ7
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  2. XM_036155903.1 → XP_036011796.1  midnolin isoform X4

  3. XM_030245189.2 → XP_030101049.1  midnolin isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TPJ7.1 GenPept UniProtKB/Swiss-Prot:Q3TPJ7

Gene LinkOut

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