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Slc22a17 solute carrier family 22 (organic cation transporter), member 17 [ Mus musculus (house mouse) ]

Gene ID: 59049, updated on 18-Apr-2024

Summary

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Official Symbol
Slc22a17provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 17provided by MGI
Primary source
MGI:MGI:1926225
See related
Ensembl:ENSMUSG00000022199 AllianceGenome:MGI:1926225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BOIT; Boct; 24p3R; 1700094C23Rik
Summary
Enables transmembrane signaling receptor activity. Involved in siderophore transport. Predicted to be located in plasma membrane. Predicted to be integral component of organelle membrane and integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human SLC22A17 (solute carrier family 22 member 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 137.6), frontal lobe adult (RPKM 136.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 27.99 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55144184..55154527, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54906727..54913132, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene embryonal Fyn-associated substrate Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis. Langelueddecke C, et al. J Biol Chem, 2012 Jan 2. PMID 22084236, Free PMC Article
  2. Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection. Betten R, et al. Cell Commun Signal, 2018 Nov 7. PMID 30404645, Free PMC Article
  3. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Devireddy LR, et al. Cell, 2005 Dec 29. PMID 16377569
  4. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lcn2-R upregulation and Lcn2 downregulation via Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD cells
    Title: Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection.
  2. 24p3R binds proteins filtered by the kidney with high affinity and may contribute to receptor-mediated endocy of proteins
    Title: Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis.
  3. cloning of the lipocalin 24p3 receptor (24p3R). Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand.
    Title: A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within iron ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 17
Names
24p3 receptor
brain-type organic cation transporter
lipocalin-2 receptor
organic cation transporter BOCT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360406.1 → NP_001347335.1  solute carrier family 22 member 17 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA271560, AK007059, BY291454, CX206695
    UniProtKB/TrEMBL
    A0A2I3BQL1
    Related
    ENSMUSP00000154165.3, ENSMUST00000228495.3
    Conserved Domains (1) summary
    cd17445
    Location:63 → 476
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

  2. NM_021551.4 → NP_067526.2  solute carrier family 22 member 17 isoform 2

    See identical proteins and their annotated locations for NP_067526.2

    Status: VALIDATED

    Source sequence(s)
    AK007059, BB809257, BY291454
    Consensus CDS
    CCDS36924.1
    UniProtKB/Swiss-Prot
    Q9D9E0, Q9WTM1
    Related
    ENSMUSP00000049676.8, ENSMUST00000050772.10
    Conserved Domains (1) summary
    cl28910
    Location:2 → 357
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55144184..55154527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247904.2 → XP_030103764.1  solute carrier family 22 member 17 isoform X2

    UniProtKB/Swiss-Prot
    Q9D9E0, Q9WTM1
    Conserved Domains (1) summary
    cl28910
    Location:2 → 357
    MFS; Major Facilitator Superfamily

  2. XM_006519338.5 → XP_006519401.1  solute carrier family 22 member 17 isoform X1

    See identical proteins and their annotated locations for XP_006519401.1

    UniProtKB/TrEMBL
    A0A2I3BQL1
    Related
    ENSMUSP00000154217.3, ENSMUST00000228119.3
    Conserved Domains (1) summary
    cd17445
    Location:63 → 476
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

RNA

  1. XR_004938424.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9E0.2 GenPept UniProtKB/Swiss-Prot:Q9D9E0

Gene LinkOut

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