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Arpp19 cAMP-regulated phosphoprotein 19 [ Mus musculus (house mouse) ]

Gene ID: 59046, updated on 11-Apr-2024

Summary

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Official Symbol
Arpp19provided by MGI
Official Full Name
cAMP-regulated phosphoprotein 19provided by MGI
Primary source
MGI:MGI:1891691
See related
Ensembl:ENSMUSG00000007656 AllianceGenome:MGI:1891691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
19kDa; Arpp12; ARPP-19; 2700024H10Rik
Summary
Predicted to enable potassium channel regulator activity; protein phosphatase inhibitor activity; and signaling receptor binding activity. Predicted to be involved in G2/M transition of mitotic cell cycle; negative regulation of protein dephosphorylation; and positive regulation of gluconeogenesis. Predicted to act upstream of or within cell division. Predicted to be active in cytoplasm. Is expressed in secondary oocyte. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 43.2), frontal lobe adult (RPKM 28.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Arpp19 in Genome Data Viewer
Location:
9 D; 9 42.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (74944896..74967595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75037614..75060313)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene one cut domain, family member 1 Neighboring gene predicted gene, 38678 Neighboring gene STARR-positive B cell enhancer ABC_E8300 Neighboring gene STARR-positive B cell enhancer ABC_E6765 Neighboring gene STARR-positive B cell enhancer ABC_E714 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74812784-74813085 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74813338-74813639 Neighboring gene microRNA 1970c Neighboring gene atos homolog A Neighboring gene STARR-seq mESC enhancer starr_24651 Neighboring gene STARR-seq mESC enhancer starr_24653 Neighboring gene STARR-positive B cell enhancer ABC_E10563 Neighboring gene predicted gene, 51714 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene myosin VA Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture. Girault JA, et al. Proc Natl Acad Sci U S A, 1988 Oct. PMID 2845422, Free PMC Article
  2. MicroRNA-320 induces neurite outgrowth by targeting ARPP-19. White RE, et al. Neuroreport, 2012 Jul 11. PMID 22617447, Free PMC Article
  3. ENSA and ARPP19 differentially control cell cycle progression and development. Hached K, et al. J Cell Biol, 2019 Feb 4. PMID 30626720, Free PMC Article
  4. ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). Andrade EC, et al. J Neurosci, 2017 Mar 8. PMID 28167675, Free PMC Article
  5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova I, et al. J Neurochem, 2001 Apr. PMID 11279279

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-regulated phosphoprotein 19
Names
cAMP-regulated phosphoprotein ARPP-19
cyclic AMP phosphoprotein, 19 kDa
cyclic AMP phosphoprotein, 19kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142655.1 → NP_001136127.1  cAMP-regulated phosphoprotein 19 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS52859.1
    UniProtKB/TrEMBL
    E9Q827
    Related
    ENSMUSP00000128921.2, ENSMUST00000169492.8
    Conserved Domains (1) summary
    pfam04667
    Location:61 → 136
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  2. NM_001357878.1 → NP_001344807.1  cAMP-regulated phosphoprotein 19 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS23340.1
    UniProtKB/Swiss-Prot
    P56212, Q543L2
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  3. NM_001357879.1 → NP_001344808.1  cAMP-regulated phosphoprotein 19 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS23340.1
    UniProtKB/Swiss-Prot
    P56212, Q543L2
    Related
    ENSMUSP00000132350.2, ENSMUST00000170308.8
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  4. NM_001357880.1 → NP_001344809.1  cAMP-regulated phosphoprotein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 5 and 6 both encode the same isoform (3).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS90623.1
    Related
    ENSMUSP00000131597.2, ENSMUST00000167885.8
    Conserved Domains (1) summary
    pfam04667
    Location:12 → 87
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  5. NM_001357881.1 → NP_001344810.1  cAMP-regulated phosphoprotein 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 5 and 6 both encode the same isoform (3).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS90623.1
    Related
    ENSMUSP00000131987.2, ENSMUST00000166549.2
    Conserved Domains (1) summary
    pfam04667
    Location:12 → 87
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

  6. NM_021548.4 → NP_067523.1  cAMP-regulated phosphoprotein 19 isoform 1

    See identical proteins and their annotated locations for NP_067523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    CT033761
    Consensus CDS
    CCDS23340.1
    UniProtKB/Swiss-Prot
    P56212, Q543L2
    Related
    ENSMUSP00000007800.8, ENSMUST00000007800.8
    Conserved Domains (1) summary
    pfam04667
    Location:28 → 103
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RNA

  1. NR_152135.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal segment compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT033761

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    74944896..74967595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56212.2 GenPept UniProtKB/Swiss-Prot:P56212

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