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Stk25 serine/threonine kinase 25 (yeast) [ Mus musculus (house mouse) ]

Gene ID: 59041, updated on 11-Apr-2024

Summary

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Official Symbol
Stk25provided by MGI
Official Full Name
serine/threonine kinase 25 (yeast)provided by MGI
Primary source
MGI:MGI:1891699
See related
Ensembl:ENSMUSG00000026277 AllianceGenome:MGI:1891699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ysk1; Ste20-like; 1500019J11Rik
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Predicted to be located in Golgi membrane. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 68.5), large intestine adult (RPKM 63.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk25 in Genome Data Viewer
Location:
1 D; 1 47.25 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93548473..93581937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93620751..93654216, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene predicted gene, 41920 Neighboring gene STARR-seq mESC enhancer starr_01730 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95532366-95532549 Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_01735

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective. Cansby E, et al. Commun Biol, 2022 Apr 19. PMID 35440683, Free PMC Article
  2. Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver. Nerstedt A, et al. J Lipid Res, 2020 Feb. PMID 31857389, Free PMC Article
  3. STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Cansby E, et al. Arterioscler Thromb Vasc Biol, 2018 Aug. PMID 29930001
  4. STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue. Sütt S, et al. J Endocrinol, 2018 Sep. PMID 29794231
  5. Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Chursa U, et al. Diabetologia, 2017 Mar. PMID 27981357, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
    Title: Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
  2. STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
    Title: STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
  3. GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
    Title: GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
  4. STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
    Title: STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
  5. Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
    Title: Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
  6. Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.
    Title: Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver.
  7. First evidence for a key function of STK25 in controlling the metabolic balance of lipid utilization vs lipid storage in brown and white adipose depots, suggesting that repression of STK25 activity offers a potential strategy for establishing healthier adipose tissue in the context of chronic exposure to dietary lipids.
    Title: STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.
  8. STK25 is one of the mediators in the complex molecular network controlling the development of atherosclerosis in hyperlipidemic mice.
    Title: STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia.
  9. a significant positive correlation in human liver biopsies between STK25 expression and nonalcoholic steatohepatitis development
    Title: STK25 is a critical determinant in nonalcoholic steatohepatitis.
  10. we challenged Stk25 knockout and wild-type mice with a high-fat diet and showed that STK25 deficiency suppressed development of hyperglycemia and hyperinsulinemia, improved glucose tolerance, reduced liver gluconeogenesis and increased insulin sensitivity
    Title: Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi reassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 25
Names
SOK-1
Ste20-like kinase
Yeast Sps1/Ste20-related kinase 1
serine/threonine kinase 25 (Ste20, yeast homolog)
ste20/oxidant stress response kinase 1
sterile 20/oxidant stress-response kinase 1
NP_067512.3
XP_006529831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021537.3 → NP_067512.3  serine/threonine-protein kinase 25

    See identical proteins and their annotated locations for NP_067512.3

    Status: VALIDATED

    Source sequence(s)
    AK148041, AK152917, AK165787, CF914439
    Consensus CDS
    CCDS15192.1
    UniProtKB/Swiss-Prot
    Q6IR17, Q9Z2W1
    UniProtKB/TrEMBL
    Q7TPV1
    Related
    ENSMUSP00000027498.8, ENSMUST00000027498.14
    Conserved Domains (1) summary
    cd06642
    Location:15 → 291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93548473..93581937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529768.3 → XP_006529831.1  serine/threonine-protein kinase 25 isoform X1

    See identical proteins and their annotated locations for XP_006529831.1

    UniProtKB/Swiss-Prot
    Q6IR17, Q9Z2W1
    UniProtKB/TrEMBL
    Q7TPV1
    Conserved Domains (1) summary
    cd06642
    Location:15 → 291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RNA

  1. XR_387188.1 RNA Sequence

  2. XR_004933994.1 RNA Sequence

  3. XR_001785363.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2W1.2 GenPept UniProtKB/Swiss-Prot:Q9Z2W1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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