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Rhot1 ras homolog family member T1 [ Mus musculus (house mouse) ]

Gene ID: 59040, updated on 11-Apr-2024

Summary

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Official Symbol
Rhot1provided by MGI
Official Full Name
ras homolog family member T1provided by MGI
Primary source
MGI:MGI:1926078
See related
Ensembl:ENSMUSG00000017686 AllianceGenome:MGI:1926078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arht1; Miro1; 2210403N23Rik; C430039G08Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in brain. Used to study motor neuron disease. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.8), bladder adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rhot1 in Genome Data Viewer
Location:
11 B5; 11 47.62 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80099844..80158736)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80208610..80267907)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 2, opposite strand Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene STARR-seq mESC enhancer starr_30143 Neighboring gene STARR-positive B cell enhancer ABC_E7025 Neighboring gene ring finger protein 135 Neighboring gene STARR-seq mESC enhancer starr_30145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:80116169-80116470 Neighboring gene rhomboid like 3 Neighboring gene RIKEN cDNA 5730455P16 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte. Xue Y, et al. J Cell Physiol, 2022 Dec. PMID 36183380
  2. Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons. Schwarz L, et al. Cells, 2022 Apr 8. PMID 35455950, Free PMC Article
  3. Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. Tseng N, et al. J Cereb Blood Flow Metab, 2021 Apr. PMID 32501156, Free PMC Article
  4. A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes. Castro IG, et al. Traffic, 2018 Mar. PMID 29364559, Free PMC Article
  5. Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Schuler MH, et al. Mol Biol Cell, 2017 Aug 1. PMID 28615318, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice.
    Title: Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice.
  2. Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.
    Title: Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.
  3. A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.
    Title: A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.
  4. Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons.
    Title: Steady-State Levels of Miro1 Linked to Phosphorylation at Serine 156 and Mitochondrial Respiration in Dopaminergic Neurons.
  5. Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.
    Title: Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.
  6. Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1.
    Title: Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1.
  7. Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
    Title: Amyloid-beta oligomers induce Parkin-mediated mitophagy by reducing Miro1.
  8. The data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhibition through decreased mitochondrial transport.
    Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
  9. Using knockout mouse embryonic fibroblasts, data show that mitochondrial Rho (Miro) GTPases Miro1 and Miro2 are required for normal mitochondrial cristae architecture and endoplasmic reticulum-mitochondria contacts Sites (ERMCS).
    Title: Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery.
  10. coupling between MCU and Miro1 as a novel mechanism modulating both mitochondrial Ca(2+) uptake and mitochondrial transport
    Title: MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11040

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitochondrion localization by microtubule attachment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial outer membrane permeabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
mitochondrial Rho GTPase 1
Names
ras homolog gene family, member T1
NP_001156826.1
NP_001156827.1
NP_001349797.1
NP_001349798.1
NP_001349799.1
NP_001391057.1
NP_001391058.1
NP_067511.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163354.2 → NP_001156826.1  mitochondrial Rho GTPase 1 isoform 2

    See identical proteins and their annotated locations for NP_001156826.1

    Status: VALIDATED

    Source sequence(s)
    AK147801, AL591426
    Consensus CDS
    CCDS48861.1
    UniProtKB/Swiss-Prot
    Q8BG51
    Related
    ENSMUSP00000017831.9, ENSMUST00000017831.16
    Conserved Domains (5) summary
    smart00174
    Location:20 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:428 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 422
    EF_assoc_1; EF hand associated
    pfam08356
    Location:234 → 314
    EF_assoc_2; EF hand associated

  2. NM_001163355.2 → NP_001156827.1  mitochondrial Rho GTPase 1 isoform 3

    See identical proteins and their annotated locations for NP_001156827.1

    Status: VALIDATED

    Source sequence(s)
    AK147801, AK167502, AL591426
    Consensus CDS
    CCDS48862.1
    UniProtKB/Swiss-Prot
    Q8BG51
    Related
    ENSMUSP00000057669.10, ENSMUST00000055056.16
    Conserved Domains (5) summary
    smart00174
    Location:20 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:428 → 594
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 422
    EF_assoc_1; EF hand associated
    pfam08356
    Location:234 → 314
    EF_assoc_2; EF hand associated

  3. NM_001362868.1 → NP_001349797.1  mitochondrial Rho GTPase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591426
    Consensus CDS
    CCDS88206.1
    Related
    ENSMUSP00000076664.8, ENSMUST00000077451.14
    Conserved Domains (4) summary
    cd01892
    Location:428 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 422
    EF_assoc_1; EF hand associated
    pfam08356
    Location:232 → 316
    EF_assoc_2; EF hand associated

  4. NM_001362869.1 → NP_001349798.1  mitochondrial Rho GTPase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591426
    Conserved Domains (4) summary
    cd01892
    Location:341 → 506
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:267 → 335
    EF_assoc_1; EF hand associated
    pfam08356
    Location:145 → 229
    EF_assoc_2; EF hand associated
    cl21455
    Location:36 → 95
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001362870.1 → NP_001349799.1  mitochondrial Rho GTPase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591426
    UniProtKB/TrEMBL
    F7ASU3
    Related
    ENSMUSP00000117941.2, ENSMUST00000134894.2
    Conserved Domains (4) summary
    cd01892
    Location:288 → 454
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    pfam08355
    Location:214 → 282
    EF_assoc_1; EF hand associated
    pfam08356
    Location:92 → 176
    EF_assoc_2; EF hand associated
    cl21455
    Location:1 → 42
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_001404128.1 → NP_001391057.1  mitochondrial Rho GTPase 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591426

  7. NM_001404129.1 → NP_001391058.1  mitochondrial Rho GTPase 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL591426

  8. NM_021536.8 → NP_067511.4  mitochondrial Rho GTPase 1 isoform 1

    See identical proteins and their annotated locations for NP_067511.4

    Status: VALIDATED

    Source sequence(s)
    AK054472, AK147801, AL591426
    Consensus CDS
    CCDS25130.1
    UniProtKB/Swiss-Prot
    Q3TJB7, Q3UGU4, Q5SYC3, Q5SYC6, Q8BG51, Q8BLW3, Q8BMH1, Q922N0, Q9D2R1, Q9JKB9
    Related
    ENSMUSP00000090533.7, ENSMUST00000092857.13
    Conserved Domains (5) summary
    smart00174
    Location:20 → 182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:428 → 605
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:16 → 182
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    pfam08355
    Location:354 → 422
    EF_assoc_1; EF hand associated
    pfam08356
    Location:234 → 314
    EF_assoc_2; EF hand associated

RNA

  1. NR_175822.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591426

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80099844..80158736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_879726.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG51.1 GenPept UniProtKB/Swiss-Prot:Q8BG51

Gene LinkOut

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