Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd14provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14provided by MGI
Primary source: MGI:MGI:1913284
See related: Ensembl:ENSMUSG00000026914 AllianceGenome:MGI:1913284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pad1; Poh1; rpm11; 2610312C03Rik; 3200001M20Rik
Summary: Predicted to enable endopeptidase activator activity; peptidase activity; and proteasome binding activity. Predicted to be involved in double-strand break repair; proteolysis; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within DNA repair and proteolysis. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 35.4), liver E14 (RPKM 33.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 35.56 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (61542038..61630720)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (61711694..61800376)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
Title: An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
T cell-specific deletion of the gene encoding the deubiquitinase POH1 compromised the development of mature T cells, especially CD4(+)Foxp3(+) Treg cells. Moreover, POH1 deficiency significantly attenuated the transition of CD25(+) Treg cell precursors into Foxp3(+) Treg cells accompanied by downregulation of interleukin 2 (IL-2)-STAT5 signaling.
Title: Requirement for POH1 in differentiation and maintenance of regulatory T cells.
Study thereby reveals that POH1-mediated deubiquitination of pro-IL-1beta is an important regulatory event that restrains inflammatory responses for the maintenance of immune homeostasis.
Title: POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Conditional knockout of Poh1 alleles results in reduced E2F1 expression in primary mouse liver cells.
Title: POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.
These results identify a novel mechanism of Mitf regulation in osteoclasts by POH1.
Title: The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA986732 (e-PCR)
- UniSTS:165170

AI849538 (e-PCR)
- UniSTS:165171

NoName (e-PCR)
- UniSTS:234406

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal-dependent deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cytosolic proteasome complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 14

Names: 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated pad1 homolog; MAD1; proteasome 26S subunit, non-ATPase 14

NP_067501.2

EC 3.4.19.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021526.2 → NP_067501.2 26S proteasome non-ATPase regulatory subunit 14

See identical proteins and their annotated locations for NP_067501.2

Status: VALIDATED

Source sequence(s)

AI448878, AK012013, BY324928

Consensus CDS

CCDS38127.1

UniProtKB/Swiss-Prot

O35593, Q3UB50, Q9CZY6

UniProtKB/TrEMBL

Q3UD26

Related

ENSMUSP00000028278.8, ENSMUST00000028278.14

Conserved Domains (1) summary

cd08069
Location:21 → 286

MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5