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Edf1 endothelial differentiation-related factor 1 [ Mus musculus (house mouse) ]

Gene ID: 59022, updated on 5-Mar-2024

Summary

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Official Symbol
Edf1provided by MGI
Official Full Name
endothelial differentiation-related factor 1provided by MGI
Primary source
MGI:MGI:1891227
See related
Ensembl:ENSMUSG00000015092 AllianceGenome:MGI:1891227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBF1; 0610008L11Rik
Summary
Predicted to enable TFIID-class transcription factor complex binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA binding activity. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and retina. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 103.6), duodenum adult (RPKM 81.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 17.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25447838..25452096)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25557824..25562084)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E273 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476 Neighboring gene MAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E1582 Neighboring gene phosphohistidine phosphatase 1 Neighboring gene apical junction component 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis. López-Victorio CJ, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376715
  2. Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis. Leidi M, et al. Cell Mol Life Sci, 2009 Aug. PMID 19554257
  3. Cloning and characterization of murine EDF-1. De Benedictis L, et al. Gene, 2001 Sep 19. PMID 11587857
  4. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
  5. Genetic loci that control vascular endothelial growth factor-induced angiogenesis. Rogers MS, et al. FASEB J, 2003 Nov. PMID 12958152

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results showed that EDF-1 inactivates the calmodulin/calcineurin/NFAT pathway via sequestration of calmodulin, during early adipogenesis.
    Title: EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis.
  2. EDF-1 is required for PPARgamma transcriptional activation during preadipocyte differentiation.
    Title: Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endothelial differentiation-related factor 1
Names
hypothetical protein 1-9
multiprotein-bridging factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021519.2 → NP_067494.1  endothelial differentiation-related factor 1

    See identical proteins and their annotated locations for NP_067494.1

    Status: VALIDATED

    Source sequence(s)
    AB030185, BB856073, CF740336
    Consensus CDS
    CCDS15780.1
    UniProtKB/Swiss-Prot
    Q99NE6, Q9JMG1
    Related
    ENSMUSP00000015236.4, ENSMUST00000015236.4
    Conserved Domains (2) summary
    cl26727
    Location:48 → 142
    aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
    pfam08523
    Location:5 → 71
    MBF1; Multiprotein bridging factor 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25447838..25452096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251920.2 → XP_030107780.1  endothelial differentiation-related factor 1 isoform X1

    Conserved Domains (1) summary
    pfam08523
    Location:4 → 72
    MBF1; Multiprotein bridging factor 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMG1.1 GenPept UniProtKB/Swiss-Prot:Q9JMG1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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