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Nup160 nucleoporin 160 [ Mus musculus (house mouse) ]

Gene ID: 59015, updated on 16-Apr-2024

Summary

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Official Symbol
Nup160provided by MGI
Official Full Name
nucleoporin 160provided by MGI
Primary source
MGI:MGI:1926227
See related
Ensembl:ENSMUSG00000051329 AllianceGenome:MGI:1926227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gtl13; 160kDa; Gtl-13; Gtl1-13; mKIAA0197; 2810011M03Rik
Summary
A structural constituent of nuclear pore. Involved in mRNA export from nucleus. Part of nuclear pore. Human ortholog(s) of this gene implicated in nephrotic syndrome type 19. Orthologous to human NUP160 (nucleoporin 160). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 4.4), CNS E11.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nup160 in Genome Data Viewer
Location:
2 E1; 2 50.32 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90504405..90570217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90677215..90739327)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5942 Neighboring gene predicted gene, 39870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90481961-90482070 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90490258-90490559 Neighboring gene predicted gene, 39871 Neighboring gene STARR-positive B cell enhancer ABC_E7838 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90519352-90519653 Neighboring gene STARR-seq mESC enhancer starr_05093 Neighboring gene STARR-seq mESC enhancer starr_05095 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene formin binding protein 4 Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene predicted gene 13772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy. Xie J, et al. Bioengineered, 2021 Dec. PMID 34533106, Free PMC Article
  2. Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes. Wang P, et al. Gene, 2018 Jul 20. PMID 29704630
  3. Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death. Sakuma S, et al. Cancer Discov, 2021 Jan. PMID 32988961, Free PMC Article
  4. Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes. Nikolova V, et al. Folia Biol (Praha), 2017. PMID 28374669
  5. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Ruivenkamp CA, et al. Nat Genet, 2002 Jul. PMID 12089527

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis.
    Title: Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis.
  2. Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.
    Title: Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.
  3. Knockdown of NUP160 impairs mouse podocytes, i.e. inhibiting cell proliferation, inducing apoptosis, autophagy and cell migration of mouse podocytes, and altering the expression and localization of podocyte associated molecules
    Title: Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes.
  4. While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
    Title: Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0197

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nephron development ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore outer ring ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup160
Names
160 kDa nucleoporin
gene trap locus 1-13 protein
gene trap locus-13
nucleoporin 160kDa
nucleoporin Nup160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418509.1 → NP_001405438.1  nuclear pore complex protein Nup160 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL714026, AL935132

  2. NM_001418510.1 → NP_001405439.1  nuclear pore complex protein Nup160 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL935132

  3. NM_001418511.1 → NP_001405440.1  nuclear pore complex protein Nup160 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL714026

  4. NM_021512.3 → NP_067487.1  nuclear pore complex protein Nup160 isoform 1

    See identical proteins and their annotated locations for NP_067487.1

    Status: VALIDATED

    Source sequence(s)
    AL714026, AL935132
    Consensus CDS
    CCDS16413.1
    UniProtKB/Swiss-Prot
    Q3TBI7, Q3TP11, Q3U250, Q6A0A7, Q7TME1, Q9CZD9, Q9Z0W3
    Related
    ENSMUSP00000059289.7, ENSMUST00000057481.7
    Conserved Domains (1) summary
    pfam11715
    Location:28 → 543
    Nup160; Nucleoporin Nup120/160

RNA

  1. NR_184761.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL714026, AL935132

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90504405..90570217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499968.5 → XP_006500031.1  nuclear pore complex protein Nup160 isoform X1

    See identical proteins and their annotated locations for XP_006500031.1

    UniProtKB/Swiss-Prot
    Q3TBI7, Q3TP11, Q3U250, Q6A0A7, Q7TME1, Q9CZD9, Q9Z0W3
    Conserved Domains (1) summary
    pfam11715
    Location:28 → 543
    Nup160; Nucleoporin Nup120/160

  2. XM_030251919.2 → XP_030107779.1  nuclear pore complex protein Nup160 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0W3.2 GenPept UniProtKB/Swiss-Prot:Q9Z0W3

Gene LinkOut

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