Rrs1 ribosome biogenesis regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rrs1provided by MGI
Official Full Name: ribosome biogenesis regulator 1provided by MGI
Primary source: MGI:MGI:1929721
See related: Ensembl:ENSMUSG00000061024 AllianceGenome:MGI:1929721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rrr; D1Ertd701e; 5730466A07Rik
Summary: Predicted to enable 5S rRNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in endoplasmic reticulum and nucleolus. Is expressed in several structures, including adrenal gland; head mesenchyme; jaw; nasal capsule; and submandibular gland primordium. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 1 A2; 1 2.08 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (9615633..9617680)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (9545408..9547455)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mammalian Rrs1 is localized both in the nucleolus as well as in the endoplasmic reticulum (ER) of neurons
Title: Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA415037 (e-PCR)
- UniSTS:158772

AU015916 (e-PCR)
- UniSTS:167288

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5S rRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribosome biogenesis regulatory protein homolog

Names: RRS1 ribosome biogenesis regulator homolog; regulator for ribosome resistance homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.