Moxd1 monooxygenase, DBH-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Moxd1provided by MGI
Official Full Name: monooxygenase, DBH-like 1provided by MGI
Primary source: MGI:MGI:1921582
See related: Ensembl:ENSMUSG00000020000 AllianceGenome:MGI:1921582
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MNCb-5203; 3230402N08Rik
Summary: Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in several structures, including brain; exocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MOXD1 (monooxygenase DBH like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 11.8), bladder adult (RPKM 5.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 11.48 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (24099415..24178681)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (24223517..24302783)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Based on its sequence and localization, MOX (monooxygenase X) is predicted to hydroxylate a hydrophobic substrate in the endoplasmic reticulum.
Title: Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dopamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in norepinephrine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in octopamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DBH-like monooxygenase protein 1

Names: DBH-related protein; monooxygenase X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021509.5 → NP_067484.2 DBH-like monooxygenase protein 1 precursor

See identical proteins and their annotated locations for NP_067484.2

Status: PROVISIONAL

Source sequence(s)

AC125010

Consensus CDS

CCDS23750.1

UniProtKB/Swiss-Prot

Q6PFA8, Q8BUZ7, Q8R394, Q9CXI3, Q9JJA6

Related

ENSMUSP00000093460.3, ENSMUST00000095784.3

Conserved Domains (3) summary

cd09631
Location:31 → 165

DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins

pfam01082
Location:186 → 314

Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain

pfam03712
Location:335 → 487

Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain