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Arhgap23 Rho GTPase activating protein 23 [ Mus musculus (house mouse) ]

Gene ID: 58996, updated on 3-Apr-2024

Summary

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Official Symbol
Arhgap23provided by MGI
Official Full Name
Rho GTPase activating protein 23provided by MGI
Primary source
MGI:MGI:3697726
See related
Ensembl:ENSMUSG00000049807 AllianceGenome:MGI:3697726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330041B18Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including aorta; brain; endocrine gland; female reproductive system; and retina. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.9), lung adult (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 60.97 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97295183..97393228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97404357..97502402)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53647 Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene STARR-seq mESC enhancer starr_30603 Neighboring gene STARR-positive B cell enhancer ABC_E10709 Neighboring gene STARR-seq mESC enhancer starr_30610 Neighboring gene RIKEN cDNA 4933428G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E11489 Neighboring gene STARR-positive B cell enhancer ABC_E11490 Neighboring gene STARR-positive B cell enhancer mm9_chr11:97394449-97394749 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene STARR-seq mESC enhancer starr_30619 Neighboring gene RIKEN cDNA 2410003L11 gene Neighboring gene STARR-seq mESC enhancer starr_30621 Neighboring gene predicted gene, 38962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  2. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
  3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 23
Names
rho-type GTPase-activating protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428751.1 → NP_001415680.1  rho GTPase-activating protein 23 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596088
    UniProtKB/TrEMBL
    B1AQY2

  2. NM_021493.3 → NP_067468.2  rho GTPase-activating protein 23 isoform 2

    See identical proteins and their annotated locations for NP_067468.2

    Status: VALIDATED

    Source sequence(s)
    AL596088
    Consensus CDS
    CCDS36293.1
    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    UniProtKB/TrEMBL
    F8VQ11
    Related
    ENSMUSP00000103227.2, ENSMUST00000107601.8
    Conserved Domains (3) summary
    cd04395
    Location:692 → 887
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:480 → 600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:479 → 598
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97295183..97393228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533867.3 → XP_006533930.1  rho GTPase-activating protein 23 isoform X6

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:158 → 560
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:23 → 138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:885 → 1080
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:673 → 793
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  2. XM_030246200.1 → XP_030102060.1  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  3. XM_036156873.1 → XP_036012766.1  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  4. XM_006533865.4 → XP_006533928.1  rho GTPase-activating protein 23 isoform X4

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:176 → 578
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:41 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:903 → 1098
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:691 → 811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  5. XM_006533866.4 → XP_006533929.1  rho GTPase-activating protein 23 isoform X5

    Related
    ENSMUSP00000112999.2, ENSMUST00000121799.8
    Conserved Domains (4) summary
    PHA03247
    Location:176 → 578
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:41 → 156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:903 → 1098
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:691 → 811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  6. XM_006533869.4 → XP_006533932.2  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  7. XM_006533868.5 → XP_006533931.2  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  8. XM_006533861.5 → XP_006533924.2  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  9. XM_006533862.5 → XP_006533925.2  rho GTPase-activating protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804 → 999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592 → 712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  10. XM_006533863.5 → XP_006533926.2  rho GTPase-activating protein 23 isoform X3

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77 → 479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:4 → 57
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:721 → 916
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:496 → 629
    PH-like; Pleckstrin homology-like domain

  11. XM_030246201.2 → XP_030102061.1  rho GTPase-activating protein 23 isoform X7

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (3) summary
    PHA03247
    Location:20 → 422
    PHA03247; large tegument protein UL36; Provisional
    cd04395
    Location:747 → 942
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:535 → 655
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  12. XM_006533871.5 → XP_006533934.1  rho GTPase-activating protein 23 isoform X9

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (3) summary
    PHA03307
    Location:3 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    cd04395
    Location:692 → 887
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:480 → 600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

  13. XM_006533874.4 → XP_006533937.1  rho GTPase-activating protein 23 isoform X10

    Conserved Domains (2) summary
    cd04395
    Location:107 → 302
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:1 → 15
    PH-like; Pleckstrin homology-like domain

  14. XM_036156874.1 → XP_036012767.1  rho GTPase-activating protein 23 isoform X11

    Conserved Domains (2) summary
    cd04395
    Location:107 → 302
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:1 → 15
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZH9.2 GenPept UniProtKB/Swiss-Prot:Q69ZH9

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