U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Treh trehalase (brush-border membrane glycoprotein) [ Mus musculus (house mouse) ]

Gene ID: 58866, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Trehprovided by MGI
Official Full Name
trehalase (brush-border membrane glycoprotein)provided by MGI
Primary source
MGI:MGI:1926230
See related
Ensembl:ENSMUSG00000032098 AllianceGenome:MGI:1926230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210412M19Rik
Summary
This gene belongs to the alpha-glucosidase family, whose members encode enzymes that carry out hydrolysis of alpha-glucoside bonds of a variety of carbohydrates. The enzyme encoded by this gene uses the disaccharide trehalose as a highly specific substrate and converts it into two glucose molecules. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Expression
Biased expression in duodenum adult (RPKM 127.9), small intestine adult (RPKM 63.2) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A5.2; 9 24.84 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44584530..44597602)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44673233..44686305)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene cDNA sequence BC049987 Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Nanthakumar NN, et al. Glycobiology, 2005 Mar. PMID 15483270
  2. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redmann M, et al. Redox Biol, 2017 Apr. PMID 28068606, Free PMC Article
  3. Cloning, characterization and mapping of the mouse trehalase (Treh) gene. Oesterreicher TJ, et al. Gene, 2001 May 30. PMID 11404018
  4. Partial characterization of murine intestinal maltase-glucoamylase. Quezada-Calvillo R, et al. Biochem Biophys Res Commun, 2002 Jul 12. PMID 12150962
  5. Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut. Bara AM, et al. Development, 2022 Dec 1. PMID 36504079, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha,alpha-trehalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha,alpha-trehalase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trehalose catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in trehalose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in brush border TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
trehalase
Names
alpha,alpha-trehalase
alpha,alpha-trehalose glucohydrolase
NP_001264776.1
NP_001264780.1
NP_067456.1
XP_006510579.1
XP_006510580.1
XP_006510581.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277847.1 → NP_001264776.1  trehalase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site causing a frameshift in the 5' coding region, and lacks an alternate exon in the 5' coding region which corrects the frameshift, compared to variant 1. It encodes isoform 2, which is shorter and contains an alternate internal segment, compared to isoform 1.
    Source sequence(s)
    AC151971
    Consensus CDS
    CCDS72222.1
    UniProtKB/TrEMBL
    E9PYP7, Q8VCS8
    Related
    ENSMUSP00000071206.6, ENSMUST00000071219.12
    Conserved Domains (1) summary
    cl17346
    Location:138 → 512
    Trehalase; Trehalase

  2. NM_001277851.1 → NP_001264780.1  trehalase isoform 3

    See identical proteins and their annotated locations for NP_001264780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an internal exon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC151971, AK002566, BX630594
    UniProtKB/TrEMBL
    Q8VCS8
    Conserved Domains (1) summary
    cl17346
    Location:108 → 483
    Trehalase

  3. NM_021481.3 → NP_067456.1  trehalase isoform 1 precursor

    See identical proteins and their annotated locations for NP_067456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC151971, AK008912, BX630594
    Consensus CDS
    CCDS23117.1
    UniProtKB/Swiss-Prot
    Q91ZS4, Q9JLT2
    Related
    ENSMUSP00000034609.5, ENSMUST00000034609.11
    Conserved Domains (2) summary
    COG1626
    Location:19 → 551
    TreA; Neutral trehalase [Carbohydrate transport and metabolism]
    pfam01204
    Location:43 → 547
    Trehalase; Trehalase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44584530..44597602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510517.3 → XP_006510580.1  trehalase isoform X2

    See identical proteins and their annotated locations for XP_006510580.1

    UniProtKB/TrEMBL
    Q8VCS8
    Conserved Domains (1) summary
    cl17346
    Location:108 → 483
    Trehalase

  2. XM_006510516.4 → XP_006510579.1  trehalase isoform X1

    See identical proteins and their annotated locations for XP_006510579.1

    Conserved Domains (1) summary
    pfam01204
    Location:3 → 508
    Trehalase

  3. XM_006510518.4 → XP_006510581.1  trehalase isoform X2

    See identical proteins and their annotated locations for XP_006510581.1

    UniProtKB/TrEMBL
    Q8VCS8
    Conserved Domains (1) summary
    cl17346
    Location:108 → 483
    Trehalase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLT2.1 GenPept UniProtKB/Swiss-Prot:Q9JLT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous