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RAD17 RAD17 checkpoint clamp loader component [ Homo sapiens (human) ]

Gene ID: 5884, updated on 11-Apr-2024

Summary

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Official Symbol
RAD17provided by HGNC
Official Full Name
RAD17 checkpoint clamp loader componentprovided by HGNC
Primary source
HGNC:HGNC:9807
See related
Ensembl:ENSG00000152942 MIM:603139; AllianceGenome:HGNC:9807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCYC; R24L; RAD24; HRAD17; RAD17SP
Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 28.4), lymph node (RPKM 9.8) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q13.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69369293..69414801)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (70195078..70240793)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68665120..68710628)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11525 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 pseudogene 1 Neighboring gene adenylate kinase 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68665899-68666448 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68710720-68711603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:68711604-68712486 Neighboring gene MARVEL domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:68737437-68737634 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:68758407-68758575 Neighboring gene ribosomal protein S27 pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk. Sun J, et al. Acta Med Okayama, 2021 Aug. PMID 34511607
  2. Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes. Fukumoto Y, et al. J Biol Chem, 2021 Aug. PMID 34174284, Free PMC Article
  3. The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification. Zhu J, et al. ACS Chem Biol, 2018 Sep 21. PMID 30063821, Free PMC Article
  4. The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex. Fukumoto Y, et al. Biochem Biophys Res Commun, 2017 Sep 2. PMID 28666868
  5. Human RAD 17 Polymorphism at Codon 546 Is Associated with the Risk of Colorectal Cancer. Yasuda Y, et al. Acta Med Okayama, 2017 Feb. PMID 28238011

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C-terminal tail of Rad17, iVERGE, binds the 9-1-1 complex independently of AAA+ ATPase domains to provide another clamp-loader interface.
    Title: The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp-loader interface.
  2. The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk.
    Title: The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk.
  3. Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes.
    Title: Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes.
  4. IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
    Title: IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
  5. The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex.
    Title: The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex.
  6. Human Rad17 is constitutively phosphorylated in vivo on a C-terminal threonine, T670. Rad17-T670 is phosphorylated by casein kinase 1delta/epsilon.
    Title: Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.
  7. The potential G-quadruplex sequence (PQS) of the RAD17 gene promoter was analyzed in different sequence contexts. With two extra nucleotides of the native sequence on either side of the G4, the structure was found to fold into a hybrid-like G4, similar to the hybrid-1 fold that the human telomere sequence can adopt.
    Title: The RAD17 Promoter Sequence Contains a Potential Tail-Dependent G-Quadruplex That Downregulates Gene Expression upon Oxidative Modification.
  8. Rad17-S667 in the C-terminal tail is constitutively phosphorylated in vivo in a casein kinase 2-dependent manner, and the phosphorylation is important for 9-1-1 interaction
    Title: Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17.
  9. DDX11 orchestrates jointly with 9-1-1 and its loader, RAD17, DNA damage tolerance at sites of bulky lesions, and endogenous abasic sites. These functions may explain the essential roles of DDX11 and its similarity with 9-1-1 during development.
    Title: Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
  10. The Rad17 C-terminal tail is a molecular switch that regulates the 9-1-1 interaction and the ATR pathway.
    Title: The polyanionic C-terminal tail of human Rad17 regulates interaction with the 9-1-1 complex.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Rad17 is required for HIV-1 Vpr-mediated G2 arrest in Rad17-specific siRNA-transfected cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rad17 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell cycle checkpoint protein RAD17
Names
RAD1 homolog
RAD17 homolog
RF-C activator 1 homolog
Rad17-like protein
cell cycle checkpoint protein (RAD17)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278622.1 → NP_001265551.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_001265551.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 5' terminal exon and lacks an internal exon in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 5, 6, 7 and 8.
    Source sequence(s)
    AL122068, BX537441
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000482775.1, ENST00000616683.4
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_002873.1 → NP_002864.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_002864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate 5' terminal sequence and lacks an internal exon in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 5, 6, 7 and 9.
    Source sequence(s)
    AF076838
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000303134.4, ENST00000305138.8
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. NM_133338.3 → NP_579916.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_579916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1). Variants 1, 5, 6, 7, 8 and 9 encode the same isoform.
    Source sequence(s)
    AF017748, AF126424, AK292487
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000346938.5, ENST00000354868.10
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. NM_133339.2 → NP_579917.1  cell cycle checkpoint protein RAD17 isoform 2

    See identical proteins and their annotated locations for NP_579917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in an alternate upstream translation start codon, when compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AF085736, BC018110
    Consensus CDS
    CCDS4003.1
    UniProtKB/Swiss-Prot
    A8K8X2, D3DWA5, O75714, O75943, Q7Z3S4, Q9UNK7, Q9UNR7, Q9UNR8, Q9UPF5
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000370151.3, ENST00000380774.7
    Conserved Domains (3) summary
    TIGR00602
    Location:13 → 652
    rad24; checkpoint protein rad24
    pfam13191
    Location:111 → 258
    AAA_16; AAA ATPase domain
    cl17190
    Location:135 → 193
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  5. NM_133340.2 → NP_579918.1  cell cycle checkpoint protein RAD17 isoform 3

    See identical proteins and their annotated locations for NP_579918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AF098533, BC018110
    Consensus CDS
    CCDS47226.1
    UniProtKB/TrEMBL
    A0A0G2JNH5
    Related
    ENSP00000350725.2, ENST00000358030.6
    Conserved Domains (1) summary
    TIGR00602
    Location:1 → 476
    rad24; checkpoint protein rad24

  6. NM_133341.2 → NP_579919.1  cell cycle checkpoint protein RAD17 isoform 4

    See identical proteins and their annotated locations for NP_579919.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the 5' UTR and an in-frame exon in the 5' coding region, when compared to variant 1. The resulting isoform (4) is shorter and lacks an internal segment in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    AF098534, BC018110
    Consensus CDS
    CCDS4005.1
    UniProtKB/TrEMBL
    A0A0G2JNH5
    Related
    ENSP00000282891.6, ENST00000282891.10
    Conserved Domains (3) summary
    pfam03215
    Location:3 → 496
    Rad17; Rad17 cell cycle checkpoint protein
    pfam13191
    Location:14 → 161
    AAA_16; AAA ATPase domain
    cl17190
    Location:38 → 96
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  7. NM_133342.3 → NP_579920.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_579920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 6, 7, 8 and 9.
    Source sequence(s)
    AF017748, AK292487, BC018110
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000346271.3, ENST00000354312.7
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  8. NM_133343.2 → NP_579921.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_579921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' terminal exon, and lacks an internal exon in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 5, 7, 8 and 9.
    Source sequence(s)
    AC145132, AL122068
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000355226.2, ENST00000361732.6
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  9. NM_133344.3 → NP_579922.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_579922.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two consecutive exons in the 5' UTR, when compared to variant 1. The encoded protein (isoform 1) is identical to that encoded by variants 1, 5, 6, 8 and 9.
    Source sequence(s)
    AF017748, AK292487, AL122068
    Consensus CDS
    CCDS4004.1
    UniProtKB/TrEMBL
    A0A0G2JPT5
    Related
    ENSP00000311227.7, ENST00000345306.10
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    69369293..69414801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009681.2 → XP_016865170.1  cell cycle checkpoint protein RAD17 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JPT5
    Conserved Domains (3) summary
    TIGR00602
    Location:2 → 641
    rad24; checkpoint protein rad24
    pfam13191
    Location:100 → 247
    AAA_16; AAA ATPase domain
    cl17190
    Location:124 → 182
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_047417461.1 → XP_047273417.1  cell cycle checkpoint protein RAD17 isoform X2

  3. XM_047417459.1 → XP_047273415.1  cell cycle checkpoint protein RAD17 isoform X1

  4. XM_047417457.1 → XP_047273413.1  cell cycle checkpoint protein RAD17 isoform X1

  5. XM_047417462.1 → XP_047273418.1  cell cycle checkpoint protein RAD17 isoform X2

  6. XM_047417458.1 → XP_047273414.1  cell cycle checkpoint protein RAD17 isoform X1

  7. XM_047417460.1 → XP_047273416.1  cell cycle checkpoint protein RAD17 isoform X1

  8. XM_047417456.1 → XP_047273412.1  cell cycle checkpoint protein RAD17 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791777.1 Reference GRCh38.p14 PATCHES

    Range
    36118..81548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333021.1 → XP_054188996.1  cell cycle checkpoint protein RAD17 isoform X1

  2. XM_054333025.1 → XP_054189000.1  cell cycle checkpoint protein RAD17 isoform X2

  3. XM_054333023.1 → XP_054188998.1  cell cycle checkpoint protein RAD17 isoform X2

  4. XM_054333020.1 → XP_054188995.1  cell cycle checkpoint protein RAD17 isoform X1

  5. XM_054333027.1 → XP_054189002.1  cell cycle checkpoint protein RAD17 isoform X2

  6. XM_054333016.1 → XP_054188991.1  cell cycle checkpoint protein RAD17 isoform X1

  7. XM_054333024.1 → XP_054188999.1  cell cycle checkpoint protein RAD17 isoform X2

  8. XM_054333022.1 → XP_054188997.1  cell cycle checkpoint protein RAD17 isoform X2

  9. XM_054333018.1 → XP_054188993.1  cell cycle checkpoint protein RAD17 isoform X1

  10. XM_054333019.1 → XP_054188994.1  cell cycle checkpoint protein RAD17 isoform X1

  11. XM_054333026.1 → XP_054189001.1  cell cycle checkpoint protein RAD17 isoform X2

  12. XM_054333017.1 → XP_054188992.1  cell cycle checkpoint protein RAD17 isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    152489..198224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329535.1 → XP_054185510.1  cell cycle checkpoint protein RAD17 isoform X1

  2. XM_054329536.1 → XP_054185511.1  cell cycle checkpoint protein RAD17 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JP78

  3. XM_054329533.1 → XP_054185508.1  cell cycle checkpoint protein RAD17 isoform X1

  4. XM_054329539.1 → XP_054185514.1  cell cycle checkpoint protein RAD17 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JP78

  5. XM_054329530.1 → XP_054185505.1  cell cycle checkpoint protein RAD17 isoform X1

  6. XM_054329538.1 → XP_054185513.1  cell cycle checkpoint protein RAD17 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JP78

  7. XM_054329537.1 → XP_054185512.1  cell cycle checkpoint protein RAD17 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JP78

  8. XM_054329534.1 → XP_054185509.1  cell cycle checkpoint protein RAD17 isoform X1

  9. XM_054329532.1 → XP_054185507.1  cell cycle checkpoint protein RAD17 isoform X1

  10. XM_054329531.1 → XP_054185506.1  cell cycle checkpoint protein RAD17 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    70195078..70240793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353029.1 → XP_054209004.1  cell cycle checkpoint protein RAD17 isoform X1

  2. XM_054353033.1 → XP_054209008.1  cell cycle checkpoint protein RAD17 isoform X2

  3. XM_054353031.1 → XP_054209006.1  cell cycle checkpoint protein RAD17 isoform X2

  4. XM_054353028.1 → XP_054209003.1  cell cycle checkpoint protein RAD17 isoform X1

  5. XM_054353035.1 → XP_054209010.1  cell cycle checkpoint protein RAD17 isoform X2

  6. XM_054353024.1 → XP_054208999.1  cell cycle checkpoint protein RAD17 isoform X1

  7. XM_054353032.1 → XP_054209007.1  cell cycle checkpoint protein RAD17 isoform X2

  8. XM_054353030.1 → XP_054209005.1  cell cycle checkpoint protein RAD17 isoform X2

  9. XM_054353027.1 → XP_054209002.1  cell cycle checkpoint protein RAD17 isoform X1

  10. XM_054353026.1 → XP_054209001.1  cell cycle checkpoint protein RAD17 isoform X1

  11. XM_054353034.1 → XP_054209009.1  cell cycle checkpoint protein RAD17 isoform X2

  12. XM_054353025.1 → XP_054209000.1  cell cycle checkpoint protein RAD17 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75943.2 GenPept UniProtKB/Swiss-Prot:O75943

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