U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slco1c1 solute carrier organic anion transporter family, member 1c1 [ Mus musculus (house mouse) ]

Gene ID: 58807, updated on 18-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slco1c1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 1c1provided by MGI
Primary source
MGI:MGI:1889679
See related
Ensembl:ENSMUSG00000030235 AllianceGenome:MGI:1889679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatp2; Oatpf; OATP-F; OATP-14; Slc21a14
Summary
Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in several processes, including organic anion transport; positive regulation of thyroid hormone generation; and thyroid hormone transport. Predicted to act upstream of or within ion transport. Located in basolateral plasma membrane. Is expressed in blood vessel; central nervous system; cochlea; and retina. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 12.2), cortex adult (RPKM 11.8) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 G2; 6 72.38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141470080..141515903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141524354..141570177)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A, cGMP inhibited Neighboring gene STARR-seq mESC enhancer starr_17689 Neighboring gene predicted gene 10400 Neighboring gene STARR-seq mESC enhancer starr_17690 Neighboring gene STARR-seq mESC enhancer starr_17691 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17693 Neighboring gene STARR-seq mESC enhancer starr_17694 Neighboring gene solute carrier organic anion transporter family, member 1b2 Neighboring gene STARR-seq mESC enhancer starr_17695 Neighboring gene solute carrier organic anion transporter family, member 1a7 Neighboring gene STARR-seq mESC enhancer starr_17696 Neighboring gene STARR-seq mESC enhancer starr_17697

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes. Schnell C, et al. Brain Struct Funct, 2015 Jan. PMID 24129767, Free PMC Article
  2. Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Tohyama K, et al. Endocrinology, 2004 Sep. PMID 15166123
  3. Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. Chen J, et al. Int J Mol Sci, 2023 Feb 9. PMID 36834863, Free PMC Article
  4. TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice. Reinwald JR, et al. Int J Mol Sci, 2022 Dec 8. PMID 36555189, Free PMC Article
  5. Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome. Maity-Kumar G, et al. Mol Metab, 2022 Dec. PMID 36270613, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
    Title: Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
  2. Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
    Title: Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
  3. Our data provide solid evidence for a unique gate-keeper function of MCT8 and OATP1C1 in SC activation, underscoring the importance of a finely tuned TH signaling during myogenesis.
    Title: Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.
  4. This study identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex
    Title: The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.
  5. The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
    Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
  6. Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
    Title: Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
  7. SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.
    Title: A transgenic approach to identify thyroxine transporter-expressing structures in brain development.
  8. expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development
    Title: Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.
  9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.
    Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
  10. basolateral localization of mOatp14 in the choroid plexus in which it may also play a role in T4 uptake.
    Title: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC90655

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier organic anion transporter family member 1C1
Names
organic anion transporter 2
organic anion transporter F
organic anion-transporting polypeptide 14
solute carrier family 21 (organic anion transporter), member 14
thyroxine transporter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177772.2 → NP_001171243.1  solute carrier organic anion transporter family member 1C1 isoform 2

    See identical proteins and their annotated locations for NP_001171243.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AC153834, AC155835
    UniProtKB/TrEMBL
    A0A0N4SUZ6
    Conserved Domains (3) summary
    cd06174
    Location:46 → 302
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:475 → 528
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:44 → 640
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. NM_021471.3 → NP_067446.1  solute carrier organic anion transporter family member 1C1 isoform 1

    See identical proteins and their annotated locations for NP_067446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
    Source sequence(s)
    AC153834, AC155835
    Consensus CDS
    CCDS20677.1
    UniProtKB/Swiss-Prot
    Q8BX54, Q9ERB5
    UniProtKB/TrEMBL
    A0A0N4SUZ6
    Related
    ENSMUSP00000032362.10, ENSMUST00000032362.12
    Conserved Domains (3) summary
    cd06174
    Location:46 → 302
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:475 → 528
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:44 → 641
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

  1. NR_149743.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the canonical translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC153834, AC155835
    Related
    ENSMUST00000135562.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    141470080..141515903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERB5.1 GenPept UniProtKB/Swiss-Prot:Q9ERB5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous