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Pga5 pepsinogen 5, group I [ Mus musculus (house mouse) ]

Gene ID: 58803, updated on 11-Apr-2024

Summary

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Official Symbol
Pga5provided by MGI
Official Full Name
pepsinogen 5, group Iprovided by MGI
Primary source
MGI:MGI:1915935
See related
Ensembl:ENSMUSG00000024738 AllianceGenome:MGI:1915935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pepf; 1110035E17Rik
Summary
Enables aspartic-type endopeptidase activity. Predicted to act upstream of or within protein metabolic process. Predicted to be located in extracellular region. Is expressed in alimentary system epithelium; extraembryonic component; placenta; and stomach. Orthologous to several human genes including PGA4 (pepsinogen A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward stomach adult (RPKM 68.7) See more
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Genomic context

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Location:
19 A; 19 7.12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10646321..10655435, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10668957..10678071, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene vacuolar protein sorting 37C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse. Chen X, et al. Biol Reprod, 2001 Oct. PMID 11566730
  2. Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Kageyama T. Cell Mol Life Sci, 2002 Feb. PMID 11915945
  3. Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling. Shi W, et al. Dev Dyn, 2022 Dec. PMID 36057966
  4. Multiple roles of epithelial heparan sulfate in stomach morphogenesis. Huang M, et al. J Cell Sci, 2018 May 29. PMID 29700203, Free PMC Article
  5. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pepsin A-5
Names
pepsin F
pepsinogen A5
pepsinogen F
NP_067428.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021453.4 → NP_067428.2  pepsin A-5 precursor

    See identical proteins and their annotated locations for NP_067428.2

    Status: VALIDATED

    Source sequence(s)
    AK053965, AK168924
    Consensus CDS
    CCDS29584.1
    UniProtKB/Swiss-Prot
    Q9D106, Q9JKE6
    Related
    ENSMUSP00000025647.6, ENSMUST00000025647.7
    Conserved Domains (3) summary
    pfam00026
    Location:74 → 386
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:16 → 44
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:64 → 385
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10646321..10655435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D106.1 GenPept UniProtKB/Swiss-Prot:Q9D106

Gene LinkOut

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