Kcnmb4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnmb4provided by MGI
Official Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4provided by MGI
Primary source: MGI:MGI:1913272
See related: Ensembl:ENSMUSG00000054934 AllianceGenome:MGI:1913272
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BKbeta4; slo-beta-4; k(VCA)beta-4; 1700058G18Rik; 2900045G12Rik
Summary: Enables calcium-activated potassium channel activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to act upstream of or within ion transport. Part of voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; hindlimb phalanx; naris; tarsus; and tooth. Orthologous to human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 65.8), cortex adult (RPKM 15.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 64.73 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (116251951..116309787, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (116417861..116473859, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclude that seizure-induced downregulation of KCNMB4 is an activity dependent mechanism that increases the excitability of DG neurons. These novel findings indicate that BK channel subtypes are not only defined by cell-specific expression, but can also be plastic depending on the recent history of neuronal excitability
Title: Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity.
These results indicate that an important role of the beta4-subunit is to reduce ryanodine receptor-BK channel functional coupling during the afterhyperpolarization component of the action potential, thereby decreasing excitability of dentate gyrus neurons.
Title: Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability.
the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption
Title: Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption.
BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining potassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function.
Title: Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit
Title: Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.
E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4
Title: 17beta-estradiol at physiological concentrations augments Ca(2+) -activated K+ currents via estrogen receptor beta in the gonadotropin-releasing hormone neuronal cell line GT1-7.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493092

BE691650 (e-PCR)
- UniSTS:208611

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-activated potassium channel subunit beta-4

Names: BK channel subunit beta-4; Slowpoke beta 4; calcium-activated potassium channel, subfamily M subunit beta-4; charybdotoxin receptor subunit beta-4; large conductance calcium-dependent potassium ion channel beta 4 subunit; maxi K channel subunit beta-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417817.1 → NP_001404746.1 calcium-activated potassium channel subunit beta-4 isoform 2

Status: VALIDATED

Source sequence(s)

AC135862, AC139376
NM_001417818.1 → NP_001404747.1 calcium-activated potassium channel subunit beta-4 isoform 3

Status: VALIDATED

Source sequence(s)

AC135862, AC139376
NM_021452.2 → NP_067427.1 calcium-activated potassium channel subunit beta-4 isoform 1

See identical proteins and their annotated locations for NP_067427.1

Status: VALIDATED

Source sequence(s)

AC135862, AC139376

Consensus CDS

CCDS24184.1

UniProtKB/Swiss-Prot

Q149I1, Q9JIN6

Related

ENSMUSP00000065384.5, ENSMUST00000068233.11

Conserved Domains (1) summary

pfam03185
Location:8 → 203

CaKB; Calcium-activated potassium channel, beta subunit