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Trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Mus musculus (house mouse) ]

Gene ID: 58800, updated on 25-Apr-2024

Summary

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Official Symbol
Trpm7provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 7provided by MGI
Primary source
MGI:MGI:1929996
See related
Ensembl:ENSMUSG00000027365 AllianceGenome:MGI:1929996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
Summary
Enables calcium channel activity; cytoskeletal protein binding activity; and kinase activity. Acts upstream of or within several processes, including calcium ion transport; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 61.76 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126633478..126718181, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126791558..126876261, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene STARR-positive B cell enhancer ABC_E11158 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene signal peptide peptidase like 2A Neighboring gene microRNA 3473g

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease. Zhang S, et al. Sci Signal, 2023 Jul 11. PMID 37433006
  2. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death. Liu M, et al. Sci Rep, 2023 May 15. PMID 37188671, Free PMC Article
  3. Effect of truncation on TRPM7 channel activity. Xie Z, et al. Channels (Austin), 2023 Dec. PMID 37040321, Free PMC Article
  4. TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System. Chang J, et al. Neurosci Bull, 2023 Jun. PMID 36920646,
  5. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. Zhong W, et al. Nat Commun, 2023 Jan 30. PMID 36717580, Free PMC Article

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential role of Mg[2+] in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
    Title: Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
  2. Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
    Title: Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
  3. TRPM7 kinase activity induces amyloid-beta degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
    Title: TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
  4. TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
    Title: TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
  5. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
    Title: TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
  6. Effect of truncation on TRPM7 channel activity.
    Title: Effect of truncation on TRPM7 channel activity.
  7. Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
    Title: Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
  8. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
    Title: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
  9. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
    Title: Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
  10. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
    Title: TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actomyosin structure organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium-dependent cell-matrix adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in varicosity ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 7
Names
channel-kinase 1
long transient receptor potential channel 7
transient receptor potential M7
transient receptor potential-phospholipase C-interacting kinase
transient receptor potential-related protein, ChaK
NP_001157797.1
NP_067425.2
XP_036018328.1
XP_036018329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164325.1 → NP_001157797.1  transient receptor potential cation channel subfamily M member 7 isoform 2

    See identical proteins and their annotated locations for NP_001157797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS50700.1
    UniProtKB/TrEMBL
    A2AI57, B9EK83
    Related
    ENSMUSP00000028843.6, ENSMUST00000028843.12
    Conserved Domains (3) summary
    smart00811
    Location:1595 → 1813
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:879 → 1100
    Ion_trans; Ion transport protein
    pfam16519
    Location:1198 → 1249
    TRPM_tetra; Tetramerization domain of TRPM

  2. NM_021450.2 → NP_067425.2  transient receptor potential cation channel subfamily M member 7 isoform 1

    See identical proteins and their annotated locations for NP_067425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS16689.1
    UniProtKB/Swiss-Prot
    A2AI58, Q8C7S7, Q8CE54, Q921Y5, Q923J1, Q925B2, Q9CUT2, Q9JLQ1
    UniProtKB/TrEMBL
    B9EK83
    Related
    ENSMUSP00000099513.4, ENSMUST00000103224.10
    Conserved Domains (3) summary
    smart00811
    Location:1596 → 1814
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:879 → 1100
    Ion_trans; Ion transport protein
    pfam16519
    Location:1198 → 1249
    TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126633478..126718181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162435.1 → XP_036018328.1  transient receptor potential cation channel subfamily M member 7 isoform X1

    UniProtKB/TrEMBL
    B9EK83
    Conserved Domains (4) summary
    TIGR00870
    Location:663 → 1113
    trp; transient-receptor-potential calcium channel protein
    cd16971
    Location:1519 → 1757
    Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7
    pfam16519
    Location:1135 → 1188
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:47 → 312
    LSDAT_euk; SLOG in TRPM

  2. XM_036162436.1 → XP_036018329.1  transient receptor potential cation channel subfamily M member 7 isoform X2

    Conserved Domains (3) summary
    TIGR00870
    Location:722 → 1172
    trp; transient-receptor-potential calcium channel protein
    pfam16519
    Location:1194 → 1247
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:106 → 371
    LSDAT_euk; SLOG in TRPM

RNA

  1. XR_001783160.3 RNA Sequence

  2. XR_001783159.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923J1.1 GenPept UniProtKB/Swiss-Prot:Q923J1

Gene LinkOut

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