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Trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Mus musculus (house mouse) ]

Gene ID: 58800, updated on 9-Dec-2024

Summary

Official Symbol
Trpm7provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 7provided by MGI
Primary source
MGI:MGI:1929996
See related
Ensembl:ENSMUSG00000027365 AllianceGenome:MGI:1929996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
Summary
Enables cytoskeletal protein binding activity; metal ion transmembrane transporter activity; and protein kinase activity. Involved in intracellular magnesium ion homeostasis; metal ion transport; and protein homotetramerization. Acts upstream of or within several processes, including actomyosin structure organization; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in several cellular components, including cytoplasmic vesicle; nucleus; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
Orthologs
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Genomic context

See Trpm7 in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126633478..126718181, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126791558..126876261, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene STARR-positive B cell enhancer ABC_E11158 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene signal peptide peptidase like 2A Neighboring gene microRNA 3473g

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 36
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables actin binding PubMed 
enables calcium channel activity  
enables calcium channel activity PubMed 
enables calcium channel activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables kinase activity PubMed 
enables magnesium ion transmembrane transporter activity  
enables metal ion binding  
enables monoatomic cation channel activity  
enables myosin binding PubMed 
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
enables zinc ion transmembrane transporter activity PubMed 
Items 1 - 25 of 36
Process Evidence Code Pubs
acts_upstream_of_or_within actomyosin structure organization PubMed 
involved_in calcium ion transmembrane transport  
involved_in calcium ion transport  
acts_upstream_of_or_within calcium ion transport PubMed 
involved_in calcium ion transport  
acts_upstream_of_or_within calcium-dependent cell-matrix adhesion PubMed 
involved_in chromatin remodeling  
involved_in intracellular magnesium ion homeostasis PubMed 
involved_in intracellular magnesium ion homeostasis  
involved_in magnesium ion transmembrane transport PubMed 
involved_in memory  
involved_in monoatomic cation homeostasis  
involved_in monoatomic cation transmembrane transport  
involved_in necroptotic process  
involved_in necroptotic process  
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
involved_in protein homotetramerization PubMed 
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in zinc ion transmembrane transport  
involved_in zinc ion transport PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle PubMed 
located_in cytoplasmic vesicle membrane  
located_in neuronal cell body  
located_in nucleus PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in ruffle PubMed 
located_in synaptic vesicle membrane  
located_in varicosity  

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 7
Names
channel-kinase 1
long transient receptor potential channel 7
transient receptor potential M7
transient receptor potential-phospholipase C-interacting kinase
transient receptor potential-related protein, ChaK
NP_001157797.1
NP_067425.2
XP_036018328.1
XP_036018329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164325.1NP_001157797.1  transient receptor potential cation channel subfamily M member 7 isoform 2

    See identical proteins and their annotated locations for NP_001157797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS50700.1
    UniProtKB/TrEMBL
    A2AI57, B9EK83
    Related
    ENSMUSP00000028843.6, ENSMUST00000028843.12
    Conserved Domains (3) summary
    smart00811
    Location:15951813
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:8791100
    Ion_trans; Ion transport protein
    pfam16519
    Location:11981249
    TRPM_tetra; Tetramerization domain of TRPM
  2. NM_021450.2NP_067425.2  transient receptor potential cation channel subfamily M member 7 isoform 1

    See identical proteins and their annotated locations for NP_067425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS16689.1
    UniProtKB/Swiss-Prot
    A2AI58, Q8C7S7, Q8CE54, Q921Y5, Q923J1, Q925B2, Q9CUT2, Q9JLQ1
    UniProtKB/TrEMBL
    B9EK83
    Related
    ENSMUSP00000099513.4, ENSMUST00000103224.10
    Conserved Domains (3) summary
    smart00811
    Location:15961814
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:8791100
    Ion_trans; Ion transport protein
    pfam16519
    Location:11981249
    TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126633478..126718181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162435.1XP_036018328.1  transient receptor potential cation channel subfamily M member 7 isoform X1

    UniProtKB/TrEMBL
    B9EK83
    Conserved Domains (4) summary
    TIGR00870
    Location:6631113
    trp; transient-receptor-potential calcium channel protein
    cd16971
    Location:15191757
    Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7
    pfam16519
    Location:11351188
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:47312
    LSDAT_euk; SLOG in TRPM
  2. XM_036162436.1XP_036018329.1  transient receptor potential cation channel subfamily M member 7 isoform X2

    Conserved Domains (3) summary
    TIGR00870
    Location:7221172
    trp; transient-receptor-potential calcium channel protein
    pfam16519
    Location:11941247
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:106371
    LSDAT_euk; SLOG in TRPM

RNA

  1. XR_001783160.3 RNA Sequence

  2. XR_001783159.3 RNA Sequence

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