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RAB27B RAB27B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5874, updated on 11-Apr-2024

Summary

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Official Symbol
RAB27Bprovided by HGNC
Official Full Name
RAB27B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9767
See related
Ensembl:ENSG00000041353 MIM:603869; AllianceGenome:HGNC:9767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C25KG
Summary
Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
18q21.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (54717857..54895516)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (54920965..55098601)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52385088..52562747)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904308 Neighboring gene DYNAP pseuodgene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:52274507-52275298 Neighboring gene dynactin associated protein Neighboring gene Sharpr-MPRA regulatory region 14135 Neighboring gene Sharpr-MPRA regulatory region 5858 Neighboring gene ribosomal protein SA pseudogene 57 Neighboring gene Sharpr-MPRA regulatory region 14713 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:52573135-52573366 Neighboring gene coiled-coil domain containing 68 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:52635171-52636370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:52642293-52643492 Neighboring gene microtubule associated protein 1 light chain 3 pseudogene Neighboring gene uncharacterized LOC107985125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer. Nambara S, et al. Cancer Genomics Proteomics, 2023 Jan-Feb. PMID 36581340, Free PMC Article
  2. Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Cheng A, et al. Stem Cell Res Ther, 2020 Dec 14. PMID 33317598, Free PMC Article
  3. Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication. Dai Y, et al. Int J Biochem Cell Biol, 2021 Feb. PMID 33285290
  4. Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux. Li R, et al. Carcinogenesis, 2020 Nov 13. PMID 32390047
  5. Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant. Tsuruda M, et al. PLoS One, 2020. PMID 32379831, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.
    Title: RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.
  2. Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.
    Title: Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis.
  3. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
  4. RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.
    Title: RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.
  5. Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.
    Title: Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer.
  6. RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.
    Title: RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer.
  7. NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
    Title: NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
  8. Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
    Title: Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
  9. Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo.
    Title: Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo.
  10. Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
    Title: Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin V binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in melanosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in platelet dense granule membrane TAS
Traceable Author Statement
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-27B
NP_001362256.1
NP_004154.2
XP_006722581.1
XP_016881402.1
XP_016881403.1
XP_024307000.1
XP_047293681.1
XP_047293682.1
XP_054174925.1
XP_054174926.1
XP_054174927.1
XP_054174928.1
XP_054174929.1
XP_054174930.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375327.1 → NP_001362256.1  ras-related protein Rab-27B

    Status: VALIDATED

    Source sequence(s)
    AC007673, AC098848, AC100776
    Consensus CDS
    CCDS11958.1
    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  2. NM_004163.4 → NP_004154.2  ras-related protein Rab-27B

    See identical proteins and their annotated locations for NP_004154.2

    Status: VALIDATED

    Source sequence(s)
    AC098848, AF329499
    Consensus CDS
    CCDS11958.1
    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6
    Related
    ENSP00000262094.4, ENST00000262094.10
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    54717857..54895516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025913.2 → XP_016881402.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  2. XM_006722518.2 → XP_006722581.1  ras-related protein Rab-27B isoform X2

    See identical proteins and their annotated locations for XP_006722581.1

    Conserved Domains (2) summary
    smart00174
    Location:12 → 170
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:6 → 156
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_017025914.2 → XP_016881403.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  4. XM_047437725.1 → XP_047293681.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  5. XM_047437726.1 → XP_047293682.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  6. XM_024451232.2 → XP_024307000.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6
    Conserved Domains (1) summary
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

RNA

  1. XR_007066208.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    54920965..55098601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318951.1 → XP_054174926.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  2. XM_054318950.1 → XP_054174925.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  3. XM_054318955.1 → XP_054174930.1  ras-related protein Rab-27B isoform X2

  4. XM_054318953.1 → XP_054174928.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  5. XM_054318952.1 → XP_054174927.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

  6. XM_054318954.1 → XP_054174929.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    B2RAB0, O00194, Q9BZB6

RNA

  1. XR_008485020.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00194.4 GenPept UniProtKB/Swiss-Prot:O00194

Gene LinkOut

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