Trim54 tripartite motif-containing 54 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim54provided by MGI
Official Full Name: tripartite motif-containing 54provided by MGI
Primary source: MGI:MGI:1889623
See related: Ensembl:ENSMUSG00000062077 AllianceGenome:MGI:1889623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MURF; MuRF3; Rnf30; MURF-3; 4930486E09Rik; 4930566I02Rik
Summary: Enables microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Part of microtubule associated complex. Is expressed in several structures, including diaphragm; heart; lung; skeletal musculature; and trunk dermomyotome. Orthologous to human TRIM54 (tripartite motif containing 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 63.3), mammary gland adult (RPKM 10.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.06 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31273956..31294970)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31116612..31137626)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus.
Title: Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus.
findings suggest that MuRF3 helps stabilize cardiac PPARalpha and PPARgamma1 in vivo to support resistance to the development of diabetic cardiomyopathy. MuRF3 also plays an unexpected role in regulating fat storage despite being found only in striated muscle.
Title: Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.
Knockdown of both MURF2 and MURF3 severely disrupts the formation of ordered Z- and M-bands, likely by perturbed tubulin dynamics
Title: Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.
muscle RING finger 1 and muscle RING finger 3 as key E3 ubiquitin ligases for the ubiquitin proteasome system-dependent turnover of sarcomeric proteins and reveal a potential basis for myosin storage myopathies
Title: Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3
Title: Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tripartite motif-containing protein 54

Names: muscle-specific RING finger protein 3; muscle-specific RING-finger protein; ring finger protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021447.2 → NP_067422.1 tripartite motif-containing protein 54

See identical proteins and their annotated locations for NP_067422.1

Status: VALIDATED

Source sequence(s)

AF294790, BY346743

Consensus CDS

CCDS19173.1

UniProtKB/Swiss-Prot

Q9ERP3

UniProtKB/TrEMBL

E9QAT9

Related

ENSMUSP00000013771.9, ENSMUST00000013771.15

Conserved Domains (3) summary

cd00162
Location:26 → 85

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:125 → 163

zf-B_box; B-box zinc finger

cl23765
Location:170 → 273

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits