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Erg28 ergosterol biosynthesis 28 [ Mus musculus (house mouse) ]

Gene ID: 58520, updated on 21-Apr-2024

Summary

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Official Symbol
Erg28provided by MGI
Official Full Name
ergosterol biosynthesis 28provided by MGI
Primary source
MGI:MGI:1915571
See related
Ensembl:ENSMUSG00000021252 AllianceGenome:MGI:1915571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF11; 0610007P14Rik; 1190004E09Rik
Summary
Predicted to enable identical protein binding activity and protein-macromolecule adaptor activity. Predicted to act upstream of or within sterol biosynthetic process. Predicted to be located in transport vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in brain and telencephalon. Orthologous to human ERG28 (ergosterol biosynthesis 28 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 36.5), placenta adult (RPKM 33.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 D2; 12 39.81 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85862221..85871667, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85815447..85824893, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded rRNA 5S 64 Neighboring gene STARR-seq mESC enhancer starr_32787 Neighboring gene feline leukemia virus subgroup C cellular receptor 2 Neighboring gene predicted gene, 40478 Neighboring gene STARR-seq mESC enhancer starr_32788 Neighboring gene STARR-seq mESC enhancer starr_32789 Neighboring gene tubulin tyrosine ligase-like family, member 5 Neighboring gene predicted gene, 51990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87310644-87310901 Neighboring gene STARR-positive B cell enhancer ABC_E5341 Neighboring gene predicted gene, 51989

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The genomic structure of c14orf1 is conserved across eukarya. Ottolenghi C, et al. Mamm Genome, 2000 Sep. PMID 10967139
  2. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920
  3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 0610007P14Rik, 1190004E09Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ergosterol biosynthetic protein 28 homolog
Names
c14orf1-like protein
probable ergosterol biosynthetic protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360451.1 → NP_001347380.1  ergosterol biosynthetic protein 28 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC138303, AI844820, DV047491
    Consensus CDS
    CCDS26063.1
    UniProtKB/Swiss-Prot
    Q3U8G1, Q9ERY9
    Conserved Domains (1) summary
    pfam03694
    Location:8 → 115
    Erg28; Erg28 like protein

  2. NM_001360813.1 → NP_001347742.1  ergosterol biosynthetic protein 28 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138303, AI851047, BE656456
    Conserved Domains (1) summary
    pfam03694
    Location:8 → 75
    Erg28; Erg28 like protein

  3. NM_021446.3 → NP_067421.1  ergosterol biosynthetic protein 28 homolog isoform 1

    See identical proteins and their annotated locations for NP_067421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC138303, AI844820, AK004480
    Consensus CDS
    CCDS26063.1
    UniProtKB/Swiss-Prot
    Q3U8G1, Q9ERY9
    Related
    ENSMUSP00000021676.6, ENSMUST00000021676.12
    Conserved Domains (1) summary
    pfam03694
    Location:8 → 115
    Erg28; Erg28 like protein

RNA

  1. NR_153807.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice donor site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138303, AI844820, AK004480

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85862221..85871667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950072.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERY9.1 GenPept UniProtKB/Swiss-Prot:Q9ERY9

Gene LinkOut

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