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Fibp fibroblast growth factor (acidic) intracellular binding protein [ Mus musculus (house mouse) ]

Gene ID: 58249, updated on 5-Mar-2024

Summary

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Official Symbol
Fibpprovided by MGI
Official Full Name
fibroblast growth factor (acidic) intracellular binding proteinprovided by MGI
Primary source
MGI:MGI:1926233
See related
Ensembl:ENSMUSG00000024911 AllianceGenome:MGI:1926233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010004G08Rik; 2010005N21Rik; 3010027N18Rik
Summary
Predicted to enable fibroblast growth factor binding activity. Predicted to be located in membrane and nuclear speck. Predicted to be active in nucleus. Orthologous to human FIBP (FGF1 intracellular binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 48.9), CNS E14 (RPKM 48.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.33 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5510626..5515080)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5460598..5465052)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31070 Neighboring gene fos-like antigen 1 Neighboring gene coiled-coil domain containing 85B Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5488369-5488552

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. Kolpakova E, et al. Biochem J, 2000 Dec 15. PMID 11104667, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acidic fibroblast growth factor intracellular-binding protein
Names
FGF-1 intracellular-binding protein
aFGF intracellular binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253832.1 → NP_001240761.1  acidic fibroblast growth factor intracellular-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001240761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122861
    Consensus CDS
    CCDS57130.1
    UniProtKB/TrEMBL
    Q8K2D8
    Related
    ENSMUSP00000025847.6, ENSMUST00000025847.7
    Conserved Domains (1) summary
    pfam05427
    Location:3 → 363
    FIBP; Acidic fibroblast growth factor binding (FIBP)

  2. NM_021438.4 → NP_067413.1  acidic fibroblast growth factor intracellular-binding protein isoform 2

    See identical proteins and their annotated locations for NP_067413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122861, AK028029
    Consensus CDS
    CCDS89310.1
    UniProtKB/Swiss-Prot
    Q9JI19
    Related
    ENSMUSP00000153409.2, ENSMUST00000225141.2
    Conserved Domains (1) summary
    pfam05427
    Location:3 → 356
    FIBP; Acidic fibroblast growth factor binding (FIBP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5510626..5515080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531805.3 → XP_006531868.1  acidic fibroblast growth factor intracellular-binding protein isoform X1

    Conserved Domains (1) summary
    pfam05427
    Location:3 → 309
    FIBP; Acidic fibroblast growth factor binding (FIBP)

  2. XM_030251010.1 → XP_030106870.1  acidic fibroblast growth factor intracellular-binding protein isoform X2

    Conserved Domains (1) summary
    pfam05427
    Location:3 → 302
    FIBP; Acidic fibroblast growth factor binding (FIBP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI19.1 GenPept UniProtKB/Swiss-Prot:Q9JI19

Gene LinkOut

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