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Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 [ Mus musculus (house mouse) ]

Gene ID: 58233, updated on 5-Mar-2024

Summary

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Official Symbol
Dnaja4provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member A4provided by MGI
Primary source
MGI:MGI:1927638
See related
Ensembl:ENSMUSG00000032285 AllianceGenome:MGI:1927638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dj4; Hsj4; mmDjA4; 1110021L12Rik
Summary
Predicted to enable chaperone binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 35.2), heart adult (RPKM 15.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54606132..54623601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54698848..54716317)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 5730494N06Rik pseudogene Neighboring gene predicted gene, 46113 Neighboring gene microRNA 5710 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene STARR-positive B cell enhancer ABC_E3830 Neighboring gene cellular retinoic acid binding protein I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Robichon C, et al. Biochim Biophys Acta, 2006 Sep. PMID 16950652
  2. Murine cDNA encoding a novel type I HSP40/DNAJ homolog, mmDjA4(1). Hata M, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978524
  3. Characterization and functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4. Abdul KM, et al. Cell Stress Chaperones, 2002 Apr. PMID 12380683, Free PMC Article
  4. Quantitative trait Loci specifying the response of body temperature to dietary restriction. Rikke BA, et al. J Gerontol A Biol Sci Med Sci, 2004 Feb. PMID 14999024
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the DnaJA4 chaperone can be viewed as a new player in cholesterol synthesis
    Title: DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway.
  2. hsc70/hsp70-dj4 chaperone pair protects the heart muscle cells from various stresses
    Title: Characterization and functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily A member 4
Names
DnaJ (Hsp40) homolog, subfamily A, member 4
heat shock protein, DNAJ-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357875.1 → NP_001344804.1  dnaJ homolog subfamily A member 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC159892, AK141909, KY499677
    UniProtKB/TrEMBL
    A0A1S6GWG8
    Conserved Domains (1) summary
    cl28246
    Location:15 → 423
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. NM_021422.4 → NP_067397.1  dnaJ homolog subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_067397.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC159892, AK076175
    Consensus CDS
    CCDS23193.1
    UniProtKB/Swiss-Prot
    B2RW09, Q543S9, Q9CTD6, Q9CUD4, Q9JMC3
    Related
    ENSMUSP00000070413.8, ENSMUST00000070070.8
    Conserved Domains (4) summary
    cd10719
    Location:135 → 201
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:106 → 332
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:2 → 394
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:7 → 65
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54606132..54623601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004935508.1 RNA Sequence

  2. XR_001778951.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMC3.1 GenPept UniProtKB/Swiss-Prot:Q9JMC3

Gene LinkOut

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