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Stk4 serine/threonine kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 58231, updated on 16-Apr-2024

Summary

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Official Symbol
Stk4provided by MGI
Official Full Name
serine/threonine kinase 4provided by MGI
Primary source
MGI:MGI:1929004
See related
Ensembl:ENSMUSG00000018209 AllianceGenome:MGI:1929004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst1; Ysk3; Kas-2
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in hippo signaling and positive regulation of substrate-dependent cell migration, cell attachment to substrate. Acts upstream of or within several processes, including animal organ development; epithelial tube morphogenesis; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in ovary; renal vasculature; and testis. Orthologous to human STK4 (serine/threonine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.9), spleen adult (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk4 in Genome Data Viewer
Location:
2 H3; 2 84.6 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163916033..163997444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164074113..164155524)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene STARR-positive B cell enhancer ABC_E6014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163910112-163910326 Neighboring gene STARR-positive B cell enhancer mm9_chr2:163954265-163954566 Neighboring gene RIKEN cDNA A730032A03 gene Neighboring gene K+ voltage-gated channel, subfamily S, 1 Neighboring gene predicted gene, 53202 Neighboring gene WAP four-disulfide core domain 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis. Liang Y, et al. Bioengineered, 2022 May. PMID 35611768, Free PMC Article
  2. Exercise training suppresses Mst1 activation and attenuates myocardial dysfunction in mice with type 1 diabetes. Zhao HX, et al. Can J Physiol Pharmacol, 2020 Nov. PMID 32687725
  3. Mst1 deletion reduces septic cardiomyopathy via activating Parkin-related mitophagy. Shang X, et al. J Cell Physiol, 2020 Jan. PMID 31215035
  4. MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells. Khan M, et al. Int J Mol Sci, 2019 May 21. PMID 31117242, Free PMC Article
  5. Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway. Feng J, et al. Cell Physiol Biochem, 2018. PMID 30537740

See all (173) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
    Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
  2. Inactivation of MST1/2 Controls Macrophage Polarization to Affect Macrophage-Related Disease via YAP and Non-YAP Mechanisms.
    Title: Inactivation of MST1/2 Controls Macrophage Polarization to Affect Macrophage-Related Disease via YAP and Non-YAP Mechanisms.
  3. Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development.
    Title: Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development.
  4. Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
    Title: Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
  5. MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.
    Title: MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.
  6. A Stk4-Foxp3-NF-kappaB p65 transcriptional complex promotes Treg cell activation and homeostasis.
    Title: A Stk4-Foxp3-NF-κB p65 transcriptional complex promotes T(reg) cell activation and homeostasis.
  7. MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.
    Title: MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.
  8. Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis.
    Title: Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis.
  9. Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.
    Title: Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.
  10. MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.
    Title: MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.
Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endocardium development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural tube formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of organ growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of hepatocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within primitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell differentiation involved in embryonic placenta development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 4
Names
STE20-like kinase MST1
Sps1/Ste20-related kinase 3
mammalian STE20-like protein kinase 1
sterile 20-like kinase 1
NP_067395.1
XP_006500026.1
XP_006500027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021420.4 → NP_067395.1  serine/threonine-protein kinase 4 precursor

    See identical proteins and their annotated locations for NP_067395.1

    Status: VALIDATED

    Source sequence(s)
    AK028838, AW046698, BY242850
    Consensus CDS
    CCDS17021.1
    UniProtKB/Swiss-Prot
    Q9JI11
    Related
    ENSMUSP00000018353.8, ENSMUST00000018353.14
    Conserved Domains (2) summary
    cd06612
    Location:26 → 281
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    pfam11629
    Location:433 → 480
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163916033..163997444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499963.5 → XP_006500026.1  serine/threonine-protein kinase 4 isoform X1

    Conserved Domains (2) summary
    pfam11629
    Location:377 → 424
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:26 → 225
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006499964.5 → XP_006500027.1  serine/threonine-protein kinase 4 isoform X2

    Conserved Domains (1) summary
    cd06612
    Location:26 → 281
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI11.1 GenPept UniProtKB/Swiss-Prot:Q9JI11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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