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Srrm3 serine/arginine repetitive matrix 3 [ Mus musculus (house mouse) ]

Gene ID: 58212, updated on 5-Mar-2024

Summary

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Official Symbol
Srrm3provided by MGI
Official Full Name
serine/arginine repetitive matrix 3provided by MGI
Primary source
MGI:MGI:1920309
See related
Ensembl:ENSMUSG00000039860 AllianceGenome:MGI:1920309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srrm2l; SRm300-like; 2900083I11Rik
Summary
Predicted to enable mRNA binding activity. Orthologous to human SRRM3 (serine/arginine repetitive matrix 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 10.3), frontal lobe adult (RPKM 8.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 75.42 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135835693..135903627)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135806860..135874773)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene STARR-positive B cell enhancer ABC_E6387 Neighboring gene predicted gene, 22450 Neighboring gene heat shock protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse. Nakano Y, et al. Life Sci Alliance, 2020 Dec. PMID 33087486, Free PMC Article
  2. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  3. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.
    Title: Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
serine/arginine repetitive matrix protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403221.1 → NP_001390150.1  serine/arginine repetitive matrix protein 3

    Status: VALIDATED

    Source sequence(s)
    AC083948, AC084162
    UniProtKB/Swiss-Prot
    Q80WV7, Q9CUV5, Q9JJ91

  2. NM_021403.3 → NP_067378.2  serine/arginine repetitive matrix protein 3

    See identical proteins and their annotated locations for NP_067378.2

    Status: VALIDATED

    Source sequence(s)
    BC051947, BC058385
    Consensus CDS
    CCDS39319.2
    UniProtKB/Swiss-Prot
    Q80WV7, Q9CUV5, Q9JJ91
    Related
    ENSMUSP00000115695.2, ENSMUST00000144211.2
    Conserved Domains (2) summary
    pfam15230
    Location:527 → 583
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135835693..135903627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504472.3 → XP_006504535.1  serine/arginine repetitive matrix protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006504535.1

    UniProtKB/Swiss-Prot
    Q80WV7, Q9CUV5, Q9JJ91
    Conserved Domains (2) summary
    pfam15230
    Location:527 → 583
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

  2. XM_036165389.1 → XP_036021282.1  serine/arginine repetitive matrix protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q80WV7, Q9CUV5, Q9JJ91
    Conserved Domains (2) summary
    pfam15230
    Location:527 → 583
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

  3. XM_036165391.1 → XP_036021284.1  serine/arginine repetitive matrix protein 3 isoform X3

    Conserved Domains (1) summary
    pfam15230
    Location:233 → 289
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus

  4. XM_036165388.1 → XP_036021281.1  serine/arginine repetitive matrix protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q80WV7, Q9CUV5, Q9JJ91
    Conserved Domains (2) summary
    pfam15230
    Location:527 → 583
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

  5. XM_036165390.1 → XP_036021283.1  serine/arginine repetitive matrix protein 3 isoform X3

    Conserved Domains (1) summary
    pfam15230
    Location:233 → 289
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus

  6. XM_036165392.1 → XP_036021285.1  serine/arginine repetitive matrix protein 3 isoform X4

    UniProtKB/TrEMBL
    H7BWX3
    Related
    ENSMUSP00000013615.8, ENSMUST00000013615.14
    Conserved Domains (1) summary
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

  7. XM_011240902.3 → XP_011239204.1  serine/arginine repetitive matrix protein 3 isoform X4

    UniProtKB/TrEMBL
    H7BWX3
    Conserved Domains (1) summary
    cd21376
    Location:34 → 101
    cwf21_SRRM3; cwf21 domain found in serine/arginine repetitive matrix protein 3 and similar proteins

  8. XM_006504475.5 → XP_006504538.1  serine/arginine repetitive matrix protein 3 isoform X5

    Conserved Domains (2) summary
    PRK13411
    Location:49 → 136
    PRK13411; molecular chaperone DnaK; Provisional
    pfam08312
    Location:56 → 98
    cwf21; cwf21 domain

  9. XM_006504473.5 → XP_006504536.1  serine/arginine repetitive matrix protein 3 isoform X2

    Conserved Domains (1) summary
    pfam15230
    Location:408 → 464
    SRRM_C; Serine/arginine repetitive matrix protein C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WV7.1 GenPept UniProtKB/Swiss-Prot:Q80WV7

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