Zbtb32 zinc finger and BTB domain containing 32 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb32provided by MGI
Official Full Name: zinc finger and BTB domain containing 32provided by MGI
Primary source: MGI:MGI:1891838
See related: Ensembl:ENSMUSG00000006310 AllianceGenome:MGI:1891838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rog; FAXF; FAZF; PLZP; Tzfp; 4930524C15Rik
Summary: Enables DNA binding activity; transcription corepressor activity; and zinc ion binding activity. Acts upstream of or within T cell proliferation; hemopoiesis; and regulation of cytokine production. Located in nuclear chromosome. Is expressed in alimentary system; genitourinary system; and respiratory system. Orthologous to human ZBTB32 (zinc finger and BTB domain containing 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 43.9), spleen adult (RPKM 2.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30289105..30302244, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30589680..30602819, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings demonstrate that ZBTB32 is a key transcription factor in CD8+ effector T cells that is required for the balanced regulation of effector versus memory responses to infection.
Title: Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
ZBTB32 is a novel negative regulator of antibody recall responses.
Title: ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
This study showed that DCIR2(+) DCs are capable of inducing antigen-specific tolerance in the face of ongoing autoimmunity; Zbtb32 is a suppressive transcription factor that controls T cell-mediated autoimmunity.
Title: DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.
Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection.
Title: The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling
Title: Tzfp represses the androgen receptor in mouse testis.
The study reports a remarkable >1000-fold upregulation of individual piRNAs in pachytene spermatocytes isolated from Tzfp-deficient murine testes.
Title: Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.
It is concluded that ROG can inhibit the expression of Th1 and Th2 cytokines by down-regulating the expression of ICOS, which might be a potential molecular target for asthma treatment.
Title: Repressor of GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible costimulator.
Rog plays an inhibitory role in allergic inflammation.
Title: Repressor of GATA negatively regulates murine contact hypersensitivity through the inhibition of type-2 allergic responses.
structure of zinc-finger domains; kinetics of DNA binding; DNA sequence-specific binding & nonsequence-specific binding occur simultaneously
Title: Structure and DNA binding characteristics of the three-Cys(2)His(2) domain of mouse testis zinc finger protein.
results indicate that ROG regulates allergic airway inflammation and airway hyperresponsiveness in a negative manner
Title: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (4)
Targeted (7) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 32

Names: GATA repressor; repressor of GATA; testis zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021397.2 → NP_067372.2 zinc finger and BTB domain-containing protein 32

See identical proteins and their annotated locations for NP_067372.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC167970, AF241232, AK015881, BY349526

Consensus CDS

CCDS21102.1

UniProtKB/Swiss-Prot

Q9D523, Q9JKD9

UniProtKB/TrEMBL

B2RQ06

Related

ENSMUSP00000103786.3, ENSMUST00000108151.3

Conserved Domains (4) summary

sd00017
Location:352 → 372

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 372

zf-C2H2; Zinc finger, C2H2 type

cl38908
Location:13 → 114

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam13465
Location:365 → 386

zf-H2C2_2; Zinc-finger double domain

RNA

NR_153655.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' end and lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC167970, AK015881, BY742457

Related

ENSMUST00000108150.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

30289105..30302244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250663.3 → XP_011248965.1 zinc finger and BTB domain-containing protein 32 isoform X3

Conserved Domains (2) summary

sd00017
Location:97 → 117

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:95 → 117

zf-C2H2; Zinc finger, C2H2 type
XM_006540246.5 → XP_006540309.1 zinc finger and BTB domain-containing protein 32 isoform X1

See identical proteins and their annotated locations for XP_006540309.1

UniProtKB/Swiss-Prot

Q9D523, Q9JKD9

UniProtKB/TrEMBL

B2RQ06

Conserved Domains (4) summary

sd00017
Location:352 → 372

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 372

zf-C2H2; Zinc finger, C2H2 type

cl38908
Location:13 → 114

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam13465
Location:365 → 386

zf-H2C2_2; Zinc-finger double domain
XM_036153306.1 → XP_036009199.1 zinc finger and BTB domain-containing protein 32 isoform X2

UniProtKB/Swiss-Prot

Q9D523, Q9JKD9

Conserved Domains (3) summary

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]

cl38908
Location:13 → 114

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00096
Location:327 → 349

zf-C2H2; Zinc finger, C2H2 type
XM_006540248.5 → XP_006540311.1 zinc finger and BTB domain-containing protein 32 isoform X2

UniProtKB/Swiss-Prot

Q9D523, Q9JKD9

Conserved Domains (3) summary

sd00017
Location:329 → 349

ZF_C2H2; C2H2 Zn finger [structural motif]

cl38908
Location:13 → 114

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00096
Location:327 → 349

zf-C2H2; Zinc finger, C2H2 type
XM_006540245.5 → XP_006540308.1 zinc finger and BTB domain-containing protein 32 isoform X1

See identical proteins and their annotated locations for XP_006540308.1

UniProtKB/Swiss-Prot

Q9D523, Q9JKD9

UniProtKB/TrEMBL

B2RQ06

Conserved Domains (4) summary

sd00017
Location:352 → 372

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:350 → 372

zf-C2H2; Zinc finger, C2H2 type

cl38908
Location:13 → 114

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam13465
Location:365 → 386

zf-H2C2_2; Zinc-finger double domain