Sertad2 SERTA domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sertad2provided by MGI
Official Full Name: SERTA domain containing 2provided by MGI
Primary source: MGI:MGI:1931026
See related: Ensembl:ENSMUSG00000049800 AllianceGenome:MGI:1931026
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sei2; SEI-2; Kiaa0127; TRIP-Br2; MNCb-1504; mKIAA0127
Summary: Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 23.4), lung adult (RPKM 9.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 13.03 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (20493166..20603023)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (20543166..20653023)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates a role for TRIP-Br2 in endoplasmic reticulum stress-induced brown adipose tissue (BAT) dysfunction, and inhibiting TRIP-Br2 could be a potential approach for counteracting obesity-induced BAT dysfunction.
Title: Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction.
Data suggest that expression of microRNA-128-3p is down-regulated during adipogenesis; an abundance of microRNA-128-3p appears to down-regulate adipogenesis and up-regulate lipolysis in adipocytes by targeting expression of Pparg (peroxisome proliferator-activated receptor gamma) and Sertad2 (SERTA domain-containing protein-2).
Title: miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2.
Transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat.
Title: The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation.
TRIP-Br2, modulates fat storage through simultaneous regulation of lipolysis, thermogenesis and oxidative metabolism.
Title: Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12683 (e-PCR)
- UniSTS:78605

AU021878 (e-PCR)
- UniSTS:164456

px-56c9 (e-PCR)
- UniSTS:257932

D11Mit80 (e-PCR), detects polymorphism
- UniSTS:126629

D11Hjk16 (e-PCR), detects polymorphism
- UniSTS:141736

RH141668 (e-PCR)
- UniSTS:223661

D11Hjk6 (e-PCR), detects polymorphism
- UniSTS:141750

MARC_5393-5394:996690344:1 (e-PCR)
- UniSTS:269501

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cell growth	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: SERTA domain-containing protein 2

Names: PHD zinc finger- and bromodomain-interacting protein 2; transcriptional regulator interacting with the PHD-bromodomain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.