Asic5 acid-sensing ion channel family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asic5provided by MGI
Official Full Name: acid-sensing ion channel family member 5provided by MGI
Primary source: MGI:MGI:1929259
See related: Ensembl:ENSMUSG00000028008 AllianceGenome:MGI:1929259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Inac; Accn5; Blinac
Summary: Enables proton channel activity and sodium channel activity. Acts upstream of or within sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human ASIC5 (acid sensing ion channel subunit family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 E3; 3 35.97 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (81889600..81928540)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (81982293..82021233)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse.
Title: Cerebellar Ataxia Caused by Type II Unipolar Brush Cell Dysfunction in the Asic5 Knockout Mouse.
expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum
Title: Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum.
rBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel.
Title: A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC).

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:488718

D3Mit229 (e-PCR), detects polymorphism
- UniSTS:129648

NoName (e-PCR)
- UniSTS:493945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info	PubMed
enables proton channel activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: acid-sensing ion channel 5

Names: acid-sensing (proton-gated) ion channel family member 5; amiloride-sensitive Na+ channel; amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive sodium channel; brain-liver-intestine amiloride-sensitive Na(+) channel; brain-liver-intestine amiloride-sensitive sodium channel

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.