Crlf2 cytokine receptor-like factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crlf2provided by MGI
Official Full Name: cytokine receptor-like factor 2provided by MGI
Primary source: MGI:MGI:1889506
See related: Ensembl:ENSMUSG00000033467 AllianceGenome:MGI:1889506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRLM2; Ly114; Tslpr
Summary: Predicted to enable cytokine activity; cytokine binding activity; and cytokine receptor activity. Acts upstream of or within inflammatory response. Located in external side of plasma membrane. Is expressed in rib. Orthologous to human CRLF2 (cytokine receptor like factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 40.0), spleen adult (RPKM 35.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.24 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (109702575..109707301, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (109554709..109559128, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts.
Title: TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts.
Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation.
Title: Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation.
Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation.
Title: Critical Role of TSLP Receptor on CD4 T Cells for Exacerbation of Skin Inflammation.
these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection
Title: Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.
A novel mouse xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed.
Title: A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis.
High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt signal pathway.
Title: A Potential Mechanism of High-Dose Ticagrelor in Modulating Platelet Activity and Atherosclerosis Mediated by Thymic Stromal Lymphopoietin Receptor.
Activating thymic stromal lymphopoietin promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.
Title: TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice.
Suggest that Treg defects in ApoE(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells and dendritic cells.
Title: Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic mice.
The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR).
Title: Structural basis of the proinflammatory signaling complex mediated by TSLP.
TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
Title: Lack of functional TSLP receptors mitigates Th2 polarization and the establishment and growth of 4T1 primary breast tumours but has different effects on tumour quantities in the lung and brain.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 2 cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytokine receptor-like factor 2

Names: TSLP receptor; cytokine receptor-like molecule 2; lymphocyte antigen 114; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin, receptor; type I cytokine receptor delta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164735.2 → NP_001158207.1 cytokine receptor-like factor 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC116718

UniProtKB/Swiss-Prot

Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5

Conserved Domains (1) summary

cd00063
Location:117 → 205

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001310694.2 → NP_001297623.1 cytokine receptor-like factor 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses alternate splice sites in the 5' and 3' regions and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC116718

Consensus CDS

CCDS80356.1

UniProtKB/TrEMBL

A0A0G2JGP1, Q05DC7

Related

ENSMUSP00000143641.2, ENSMUST00000200284.5

Conserved Domains (1) summary

cd00063
Location:115 → 203

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_016715.5 → NP_057924.3 cytokine receptor-like factor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_057924.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AC116718

Consensus CDS

CCDS19521.1

UniProtKB/Swiss-Prot

Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5

UniProtKB/TrEMBL

A0A0R4J0F5

Related

ENSMUSP00000036326.8, ENSMUST00000044579.12

Conserved Domains (1) summary

cd00063
Location:117 → 205

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

NR_189326.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116718
NR_189327.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116718
NR_189328.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116718
NR_189329.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116718
NR_189330.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC116718

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

109702575..109707301 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165384.1 → XP_036021277.1 cytokine receptor-like factor 2 isoform X2

UniProtKB/TrEMBL

Q3TCZ1

Related

ENSMUSP00000142982.2, ENSMUST00000198960.2

Conserved Domains (1) summary

cd00063
Location:15 → 103

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...