Cdc42se1 CDC42 small effector 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42se1provided by MGI
Official Full Name: CDC42 small effector 1provided by MGI
Primary source: MGI:MGI:1889510
See related: Ensembl:ENSMUSG00000046722 AllianceGenome:MGI:1889510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCIP1; Spec1; Cdcse1; 1300002M12Rik
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to act upstream of or within negative regulation of JNK cascade; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in cell cortex and cell junction. Predicted to be active in plasma membrane. Is expressed in cerebral cortex. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 34.7), thymus adult (RPKM 34.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95135735..95143735)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95228424..95236424)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_16118-16119:1018032271:1 (e-PCR)
- UniSTS:267966

AW558204 (e-PCR)
- UniSTS:185549

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CDC42 small effector protein 1

Names: small protein effector 1 of Cdc42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038708.3 → NP_001033797.1 CDC42 small effector protein 1

See identical proteins and their annotated locations for NP_001033797.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK004859, BC060964, CF105339, CJ290563

Consensus CDS

CCDS38545.1

UniProtKB/Swiss-Prot

Q8BHL7

Related

ENSMUSP00000102819.3, ENSMUST00000107201.9

Conserved Domains (1) summary

cl00113
Location:29 → 67

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
NM_172395.3 → NP_765983.1 CDC42 small effector protein 1

See identical proteins and their annotated locations for NP_765983.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK004859, AV456394, CJ290563

Consensus CDS

CCDS38545.1

UniProtKB/Swiss-Prot

Q8BHL7

Related

ENSMUSP00000052986.6, ENSMUST00000053872.12

Conserved Domains (1) summary

cl00113
Location:29 → 67

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...