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Gsdma gasdermin A [ Mus musculus (house mouse) ]

Gene ID: 57911, updated on 21-Apr-2024

Summary

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Official Symbol
Gsdmaprovided by MGI
Official Full Name
gasdermin Aprovided by MGI
Primary source
MGI:MGI:1889509
See related
Ensembl:ENSMUSG00000017204 AllianceGenome:MGI:1889509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gsdm; Gsdm1; H312E; Gsdma1
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in apoptotic process; defense response to bacterium; and pyroptosis. Predicted to act upstream of or within programmed cell death. Located in cytoplasm. Is expressed in esophagus epithelium; stomach; stomach cardiac region; stomach glandular region; and stomach glandular region mucosa. Orthologous to human GSDMA (gasdermin A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 18.5), testis adult (RPKM 2.8) and 1 other tissue See more
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Genomic context

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Location:
11 D; 11 62.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98555163..98568534)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98664337..98677708)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30672 Neighboring gene gasdermin A3 Neighboring gene gasdermin A2 Neighboring gene STARR-positive B cell enhancer ABC_E7059 Neighboring gene STARR-seq mESC enhancer starr_30673 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98543708-98543891 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Neighboring gene predicted gene, 38985 Neighboring gene colony stimulating factor 3 (granulocyte)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. Tanaka S, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979942, Free PMC Article
  2. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Deng W, et al. Nature, 2022 Feb. PMID 35110732, Free PMC Article
  3. CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis. Fu L, et al. Bioengineered, 2022 Feb. PMID 35034587, Free PMC Article
  4. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Saeki N, et al. Mamm Genome, 2000 Sep. PMID 10967128
  5. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Tamura M, et al. Genomics, 2007 May. PMID 17350798

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
    Title: Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
  2. CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.
    Title: CircularRNA circ_0071269 knockdown protects against from diabetic cardiomyopathy injury by microRNA-145/gasdermin A axis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gasdermin-A
Names
gasdermin 1
gasdermin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021347.4 → NP_067322.1  gasdermin-A

    See identical proteins and their annotated locations for NP_067322.1

    Status: VALIDATED

    Source sequence(s)
    AK028698
    Consensus CDS
    CCDS25358.1
    UniProtKB/Swiss-Prot
    A3KFN3, Q9EST1
    Related
    ENSMUSP00000017348.3, ENSMUST00000017348.3
    Conserved Domains (1) summary
    pfam04598
    Location:3 → 419
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98555163..98568534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533850.1 → XP_006533913.1  gasdermin-A isoform X1

    Conserved Domains (2) summary
    pfam04598
    Location:3 → 234
    Gasdermin; Gasdermin family
    pfam17708
    Location:273 → 436
    Gasdermin_C; Gasdermin PUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EST1.1 GenPept UniProtKB/Swiss-Prot:Q9EST1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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