U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il17re interleukin 17 receptor E [ Mus musculus (house mouse) ]

Gene ID: 57890, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Il17reprovided by MGI
Official Full Name
interleukin 17 receptor Eprovided by MGI
Primary source
MGI:MGI:1889371
See related
Ensembl:ENSMUSG00000043088 AllianceGenome:MGI:1889371
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il25r; IL-17RE
Summary
Predicted to enable interleukin-17 receptor activity. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Predicted to be integral component of membrane. Is expressed in urinary system. Orthologous to human IL17RE (interleukin 17 receptor E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 20.6), bladder adult (RPKM 19.2) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 E3; 6 52.76 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113435659..113447719)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113458699..113470758)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871 Neighboring gene STARR-positive B cell enhancer ABC_E8122 Neighboring gene jagunal homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113408068-113408221 Neighboring gene predicted gene, 52872 Neighboring gene interleukin 17 receptor C Neighboring gene STARR-positive B cell enhancer ABC_E684 Neighboring gene STARR-seq mESC enhancer starr_17041 Neighboring gene cysteine-rich with EGF-like domains 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma. Vella G, et al. Respir Res, 2020 Jul 8. PMID 32641167, Free PMC Article
  2. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy. Wang J, et al. Int Immunopharmacol, 2023 Jul. PMID 37235960
  3. Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model. Wang J, et al. Am J Pathol, 2022 Feb. PMID 35144761
  4. IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection. Hansakon A, et al. J Immunol, 2020 Aug 1. PMID 32561567
  5. Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia. Steck P, et al. Infect Immun, 2019 Nov. PMID 31481409, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
    Title: Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
  2. Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model.
    Title: Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model.
  3. The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.
    Title: The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.
  4. IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection.
    Title: IL-25 Receptor Signaling Modulates Host Defense against Cryptococcus neoformans Infection.
  5. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
    Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
  6. These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of S. pneumoniae lung infection.
    Title: Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia.
  7. In mouse models of crescentic GN (nephrotoxic nephritis) and pristane-induced lupus nephritis, deficiency of the unique IL-17C receptor IL-17 receptor E (IL-17RE) provided protection against crescentic GN. IL-17RE was highly expressed by CD4(+) TH17 cells.
    Title: IL-17C/IL-17 Receptor E Signaling in CD4(+) T Cells Promotes T(H)17 Cell-Driven Glomerular Inflammation.
  8. IL-17C and IL-17RE are dispensable for immunity to candidiasis
    Title: Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.
  9. IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
    Title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
  10. IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IkappaBzeta, in Th17 cells to potentiate the Th17 cell response
    Title: Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-17 receptor E
Names
IL-17 receptor E

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034029.2 → NP_001029201.1  interleukin-17 receptor E isoform 2

    See identical proteins and their annotated locations for NP_001029201.1

    Status: VALIDATED

    Source sequence(s)
    AC153910, AK044815, DQ092340
    Consensus CDS
    CCDS20421.1
    UniProtKB/Swiss-Prot
    Q8BH06
    Related
    ENSMUSP00000054378.5, ENSMUST00000053569.7
    Conserved Domains (2) summary
    pfam08357
    Location:247 → 374
    SEFIR; SEFIR domain
    pfam15037
    Location:1 → 207
    IL17_R_N; Interleukin-17 receptor extracellular region

  2. NM_001034031.2 → NP_001029203.1  interleukin-17 receptor E isoform 2

    See identical proteins and their annotated locations for NP_001029203.1

    Status: VALIDATED

    Source sequence(s)
    AC153910, AK044815, DQ092341
    Consensus CDS
    CCDS20421.1
    UniProtKB/Swiss-Prot
    Q8BH06
    Related
    ENSMUSP00000098626.2, ENSMUST00000101065.8
    Conserved Domains (2) summary
    pfam08357
    Location:247 → 374
    SEFIR; SEFIR domain
    pfam15037
    Location:1 → 207
    IL17_R_N; Interleukin-17 receptor extracellular region

  3. NM_001362204.1 → NP_001349133.1  interleukin-17 receptor E isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153910, AK044815, BC069861
    Consensus CDS
    CCDS90102.1
    Related
    ENSMUSP00000145345.2, ENSMUST00000203661.3
    Conserved Domains (2) summary
    pfam15037
    Location:56 → 408
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:406 → 529
    TIR_2; TIR domain

  4. NM_001362205.1 → NP_001349134.1  interleukin-17 receptor E isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC153910, AF458068, AK044815
    Consensus CDS
    CCDS90101.1
    Related
    ENSMUSP00000145384.2, ENSMUST00000204774.3
    Conserved Domains (2) summary
    pfam08357
    Location:428 → 555
    SEFIR; SEFIR domain
    pfam15037
    Location:56 → 408
    IL17_R_N; Interleukin-17 receptor extracellular region

  5. NM_145826.6 → NP_665825.2  interleukin-17 receptor E isoform 1 precursor

    See identical proteins and their annotated locations for NP_665825.2

    Status: VALIDATED

    Source sequence(s)
    AC153910
    Consensus CDS
    CCDS20420.1
    UniProtKB/Swiss-Prot
    Q3I5F0, Q6NSU9, Q8BH06, Q8C5D0, Q8K4C1, Q8R335
    Related
    ENSMUSP00000062103.8, ENSMUST00000058548.14
    Conserved Domains (2) summary
    pfam08357
    Location:448 → 575
    SEFIR; SEFIR domain
    pfam15037
    Location:27 → 408
    IL17_R_N; Interleukin-17 receptor extracellular region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113435659..113447719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255519.2 → XP_030111379.1  interleukin-17 receptor E isoform X1

    Conserved Domains (2) summary
    pfam08357
    Location:247 → 374
    SEFIR; SEFIR domain
    pfam15037
    Location:1 → 207
    IL17_R_N; Interleukin-17 receptor extracellular region

  2. XM_036152248.1 → XP_036008141.1  interleukin-17 receptor E isoform X1

    Conserved Domains (2) summary
    pfam08357
    Location:247 → 374
    SEFIR; SEFIR domain
    pfam15037
    Location:1 → 207
    IL17_R_N; Interleukin-17 receptor extracellular region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH06.1 GenPept UniProtKB/Swiss-Prot:Q8BH06

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous