Tesc tescalcin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tescprovided by MGI
Official Full Name: tescalcinprovided by MGI
Primary source: MGI:MGI:1930803
See related: Ensembl:ENSMUSG00000029359 AllianceGenome:MGI:1930803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TE-1; 1010001A17Rik; 2410011K10Rik
Summary: Enables metal ion binding activity; phosphatase inhibitor activity; and protein homodimerization activity. Acts upstream of or within male gonad development and megakaryocyte differentiation. Located in several cellular components, including lamellipodium; nucleus; and ruffle. Is expressed in several structures, including adrenal gland; brain; gonad; metanephros; and sensory organ. Orthologous to human TESC (tescalcin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 325.4), stomach adult (RPKM 168.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 57.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (118165808..118199943)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (118027743..118061878)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TESC has an important role in mediating the neuroprotective effect of class I histone deacetylase inhibitors, and may also be involved in the development of brain and neurodegenerative diseases through epigenetic mechanisms
Title: Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.
Tescalcin does not appear to be necessary for normal megakaryocyte development
Title: Megakaryocyte development is normal in mice with targeted disruption of Tescalcin.
CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
Title: CIB1 is a regulator of pathological cardiac hypertrophy.
the data demonstrated that Sp1 and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter, and that the putative ZF5 motif is critical for its activation.
Title: Structural and functional characterization of the mouse tescalcin promoter.
Studies indicate very specific expression of Tesc in various tissues in chicken and mouse during embryologic development, and conservation of Tesc expression in both species.
Title: Expression and evolutionary conservation of the tescalcin gene during development.
Tescalcin shares sequence and functional homology with calcineurin-B homologous protein (CHP), and like CHP can inhibit the phosphatase activity of calcineurin A.
Title: Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tesc (e-PCR), detects polymorphism
- UniSTS:547853

Tesc-pending (e-PCR), detects polymorphism
- UniSTS:224096

Tesc (e-PCR), detects polymorphism
- UniSTS:502674

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcineurin B homologous protein 3

Names: CHP3; TSC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021344.4 → NP_067319.2 calcineurin B homologous protein 3

See identical proteins and their annotated locations for NP_067319.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC114993, BE979843, CX242767

Consensus CDS

CCDS19608.1

UniProtKB/Swiss-Prot

Q32Q85, Q8VCN1, Q9JKL5

UniProtKB/TrEMBL

D0EM45

Related

ENSMUSP00000031304.8, ENSMUST00000031304.14

Conserved Domains (1) summary

COG5126
Location:20 → 142

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RNA

NR_151582.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC114993

Related

ENSMUST00000124648.8