Cdon cell adhesion molecule-related/down-regulated by oncogenes [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdonprovided by MGI
Official Full Name: cell adhesion molecule-related/down-regulated by oncogenesprovided by MGI
Primary source: MGI:MGI:1926387
See related: Ensembl:ENSMUSG00000038119 AllianceGenome:MGI:1926387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDO; Cd0; Orcam
Summary: Acts upstream of or within several processes, including animal organ development; positive regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb bud; and sensory organ. Used to study holoprosencephaly 11. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 17.8), CNS E14 (RPKM 6.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.24 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (35332836..35418948)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (35421528..35507652)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis.
Title: Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis.
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Title: Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Compound heterozygous splicing CDON variants result in isolated ocular coloboma.
Title: Compound heterozygous splicing CDON variants result in isolated ocular coloboma.
Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.
Title: Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly.
The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Title: The hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development.
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Title: Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
Title: The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.
Cdon deficiency causes hyperactive Wnt signaling leading to aberrant intercellular coupling and cardiac fibrosis.
Title: Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh signaling activity.
Title: Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia.
Mutation in the Cdon gene is associated with congenital nevus development.
Title: A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S840 (e-PCR)
- UniSTS:148765

NoName (e-PCR)
- UniSTS:236088

D9Mit127 (e-PCR), detects polymorphism
- UniSTS:131676

AF090866 (e-PCR)
- UniSTS:159860

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of striated muscle tissue development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within skeletal muscle satellite cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cell adhesion molecule-related/down-regulated by oncogenes

Names: CAM-related/down-regulated by oncogenes; immunoglobulin superfamily member CDO; oncogene-regulated cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405246.1 → NP_001392175.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9
NM_001405247.1 → NP_001392176.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9
NM_001405248.1 → NP_001392177.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9
NM_001405249.1 → NP_001392178.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9
NM_001405250.1 → NP_001392179.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9
NM_001405251.1 → NP_001392180.1 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Related

ENSMUSP00000045547.6, ENSMUST00000042842.6
NM_021339.3 → NP_067314.2 cell adhesion molecule-related/down-regulated by oncogenes precursor

See identical proteins and their annotated locations for NP_067314.2

Status: VALIDATED

Source sequence(s)

AC118232, AC159894

Consensus CDS

CCDS22964.1

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Related

ENSMUSP00000113977.2, ENSMUST00000119129.10

Conserved Domains (6) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

35332836..35418948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155157.1 → XP_036011050.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Conserved Domains (6) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_006510512.5 → XP_006510575.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X2

Conserved Domains (5) summary

smart00408
Location:325 → 386

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cl11960
Location:33 → 113

Ig; Immunoglobulin domain
XM_006510514.5 → XP_006510577.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155159.1 → XP_036011052.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155158.1 → XP_036011051.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155161.1 → XP_036011054.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155162.1 → XP_036011055.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155160.1 → XP_036011053.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X3

UniProtKB/TrEMBL

Q3TZM7

Related

ENSMUSP00000117499.2, ENSMUST00000154652.8

Conserved Domains (5) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155154.1 → XP_036011047.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Conserved Domains (6) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155156.1 → XP_036011049.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Conserved Domains (6) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_036155155.1 → XP_036011048.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/Swiss-Prot

E9QKV9, O88971, Q32MD9

Conserved Domains (6) summary

smart00408
Location:236 → 296

IGc2; Immunoglobulin C-2 Type

cd00063
Location:717 → 807

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:594 → 662

fn3; Fibronectin type III domain

pfam07679
Location:404 → 516

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain