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Rbak RB-associated KRAB zinc finger [ Mus musculus (house mouse) ]

Gene ID: 57782, updated on 11-Apr-2024

Summary

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Official Symbol
Rbakprovided by MGI
Official Full Name
RB-associated KRAB zinc fingerprovided by MGI
Primary source
MGI:MGI:1927369
See related
Ensembl:ENSMUSG00000061898 AllianceGenome:MGI:1927369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to several human genes including RBAK-RBAKDN (RBAK-RBAKDN readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.1), CNS E11.5 (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rbak in Genome Data Viewer
Location:
5 G2; 5 81.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143157941..143166530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143172186..143180775, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7291 Neighboring gene RB-associated KRAB zinc finger downstream neighbor (non-protein coding) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143942516-143942699 Neighboring gene speedy/RINGO cell cycle regulator family, member E4B Neighboring gene speedy/RINGO cell cycle regulator family, member E4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. Skapek SX, et al. J Biol Chem, 2000 Mar 10. PMID 10702291
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RB-associated KRAB zinc finger protein
Names
RB-associated KRAB repressor
zinc finger protein 769

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045482.2 → NP_001038947.1  RB-associated KRAB zinc finger protein

    See identical proteins and their annotated locations for NP_001038947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC123686, AK051009, CN699599
    Consensus CDS
    CCDS19835.1
    UniProtKB/Swiss-Prot
    Q6PB38, Q8BQC8, Q9JKU4
    Related
    ENSMUSP00000059273.5, ENSMUST00000049861.11
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:340 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:314 → 336
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001359235.1 → NP_001346164.1  RB-associated KRAB zinc finger protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC123686
    Consensus CDS
    CCDS19835.1
    UniProtKB/Swiss-Prot
    Q6PB38, Q8BQC8, Q9JKU4
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:340 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:314 → 336
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_021326.3 → NP_067301.1  RB-associated KRAB zinc finger protein

    See identical proteins and their annotated locations for NP_067301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC123686, AK051009
    Consensus CDS
    CCDS19835.1
    UniProtKB/Swiss-Prot
    Q6PB38, Q8BQC8, Q9JKU4
    Related
    ENSMUSP00000128731.2, ENSMUST00000165318.4
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:340 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:314 → 336
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143157941..143166530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQC8.1 GenPept UniProtKB/Swiss-Prot:Q8BQC8

Gene LinkOut

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