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TRIB3 tribbles pseudokinase 3 [ Homo sapiens (human) ]

Gene ID: 57761, updated on 7-Apr-2024

Summary

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Official Symbol
TRIB3provided by HGNC
Official Full Name
tribbles pseudokinase 3provided by HGNC
Primary source
HGNC:HGNC:16228
See related
Ensembl:ENSG00000101255 MIM:607898; AllianceGenome:HGNC:16228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIPK; SINK; TRB3; SKIP3; C20orf97
Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more
Orthologs
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Genomic context

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See TRIB3 in Genome Data Viewer
Location:
20p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (380760..397559)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (424107..440963)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (361404..378203)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12568 Neighboring gene Sharpr-MPRA regulatory region 7859/9812 Neighboring gene SRY-box transcription factor 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:326527-327290 Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:327291-328053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:328054-328816 Neighboring gene Sharpr-MPRA regulatory region 10349 Neighboring gene Sharpr-MPRA regulatory region 12668 Neighboring gene neurensin 2 Neighboring gene Sharpr-MPRA regulatory region 10396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:345627-346226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:362523-363521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:379646-380146 Neighboring gene CRISPRi-validated cis-regulatory element chr20.29 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:386661-386817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:388888-389530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:389531-390171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12576 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:410614-411114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:411115-411615 Neighboring gene TBC1 domain family member 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:442560-442708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer. Arif A, et al. Int Immunopharmacol, 2023 Jan. PMID 36527874
  2. High TRB3 expression induces chondrocyte autophagy and senescence in osteoarthritis cartilage. Gu Y, et al. Aging (Albany NY), 2022 Jul 1. PMID 35776529, Free PMC Article
  3. Increased expression of tribbles homolog 3 predicts poor prognosis and correlates with tumor immunity in clear cell renal cell carcinoma: a bioinformatics study. Wu XQ, et al. Bioengineered, 2022 May. PMID 35726370, Free PMC Article
  4. Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer. Zhou W, et al. BMC Cancer, 2022 Apr 26. PMID 35473511, Free PMC Article
  5. TRIB3 Promotes Osteogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells Levelled by Post-transcriptional Regulation of miR-24-3p. Bai XS, et al. Chin J Dent Res, 2021 Dec 23. PMID 35029095

See all (163) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2.
    Title: TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2.
  2. TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
    Title: TRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis.
  3. Integration of dietary nutrition and TRIB3 action into diabetes mellitus.
    Title: Integration of dietary nutrition and TRIB3 action into diabetes mellitus.
  4. TRIB3, as a robust prognostic biomarker for HNSC, is associated with poor immune infiltration and cancer cell immune evasion.
    Title: TRIB3, as a robust prognostic biomarker for HNSC, is associated with poor immune infiltration and cancer cell immune evasion.
  5. Transcription Factor Sox9 Exacerbates Kidney Injury through Inhibition of MicroRNA-96-5p and Activation of the Trib3/IL-6 Axis.
    Title: Transcription Factor Sox9 Exacerbates Kidney Injury through Inhibition of MicroRNA-96-5p and Activation of the Trib3/IL-6 Axis.
  6. A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
    Title: A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
  7. Upregulation of Tribbles decreases body weight and increases sleep duration.
    Title: Upregulation of Tribbles decreases body weight and increases sleep duration.
  8. The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.
    Title: The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer.
  9. TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.
    Title: TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF.
  10. TRIB3 Interacts with STAT3 to Promote Cancer Angiogenesis.
    Title: TRIB3 Interacts with STAT3 to Promote Cancer Angiogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (123)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glucose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tribbles homolog 3
Names
TRB-3
neuronal cell death inducible putative kinase
p65-interacting inhibitor of NF-kappa-B
p65-interacting inhibitor of NF-kappaB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301188.1 → NP_001288117.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as 1B1) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697937, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
    UniProtKB/TrEMBL
    B4DMM9
    Conserved Domains (1) summary
    cd14024
    Location:74 → 315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

  2. NM_001301190.1 → NP_001288119.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 1B2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697938, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
    UniProtKB/TrEMBL
    B4DMM9
    Conserved Domains (1) summary
    cd14024
    Location:74 → 315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

  3. NM_001301193.1 → NP_001288122.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288122.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as 1B3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697939, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
    UniProtKB/TrEMBL
    B4DMM9
    Conserved Domains (1) summary
    cd14024
    Location:74 → 315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

  4. NM_001301196.1 → NP_001288125.1  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_001288125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as 1B4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AJ697936, AJ697940, BC019363
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
    UniProtKB/TrEMBL
    B4DMM9
    Conserved Domains (1) summary
    cd14024
    Location:74 → 315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

  5. NM_001301201.1 → NP_001288130.1  tribbles homolog 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' UTR exon and an additional exon in the 5' region, which results in an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AJ697940, AK297546, BC019363
    Consensus CDS
    CCDS77554.1
    UniProtKB/TrEMBL
    B4DMM9, J3KR25
    Related
    ENSP00000415416.2, ENST00000422053.3
    Conserved Domains (2) summary
    smart00220
    Location:107 → 342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14024
    Location:101 → 342
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

  6. NM_021158.5 → NP_066981.2  tribbles homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_066981.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 1A) represents the longest transcript and encode the predominant isoform (1).
    Source sequence(s)
    AL034548
    Consensus CDS
    CCDS12997.1
    UniProtKB/Swiss-Prot
    Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
    UniProtKB/TrEMBL
    B4DMM9
    Related
    ENSP00000217233.3, ENST00000217233.9
    Conserved Domains (1) summary
    cd14024
    Location:74 → 315
    PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    380760..397559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    424107..440963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RU7.2 GenPept UniProtKB/Swiss-Prot:Q96RU7

Gene LinkOut

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