U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pglyrp2 peptidoglycan recognition protein 2 [ Mus musculus (house mouse) ]

Gene ID: 57757, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pglyrp2provided by MGI
Official Full Name
peptidoglycan recognition protein 2provided by MGI
Primary source
MGI:MGI:1928099
See related
Ensembl:ENSMUSG00000079563 AllianceGenome:MGI:1928099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tagL; PGRP-L; Pglyrpl; C730002N09Rik
Summary
Predicted to enable N-acetylmuramoyl-L-alanine amidase activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Acts upstream of or within several processes, including negative regulation of interferon-gamma production; negative regulation of natural killer cell differentiation involved in immune response; and regulation of inflammatory response. Predicted to be located in extracellular region and membrane. Is expressed in hemolymphoid system and thymus primordium. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 42.8), thymus adult (RPKM 34.2) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 B1; 17 17.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32631433..32643157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32412459..32424219, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene widely-interspaced zinc finger motifs Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene predicted gene, 53995 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene RAS protein activator like 3 Neighboring gene predicted gene, 41569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32561046-32561233 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene STARR-seq mESC enhancer starr_42380 Neighboring gene STARR-seq mESC enhancer starr_42381 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17 Neighboring gene STARR-seq mESC enhancer starr_42382 Neighboring gene STARR-seq mESC enhancer starr_42383 Neighboring gene STARR-positive B cell enhancer ABC_E8998

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection. Dabrowski AN, et al. Front Microbiol, 2019. PMID 30837960, Free PMC Article
  2. Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice. Arentsen T, et al. Brain Behav Immun, 2018 Jan. PMID 28951252
  3. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Duerr CU, et al. Mucosal Immunol, 2011 May. PMID 20980996
  4. Mammalian peptidoglycan recognition protein TagL inhibits Listeria monocytogenes invasion into epithelial cells. Kibardin A, et al. FEMS Immunol Med Microbiol, 2006 Mar. PMID 16487310
  5. The differentially spliced mouse tagL gene, homolog of tag7/PGRP gene family in mammals and Drosophila, can recognize Gram-positive and Gram-negative bacterial cell wall independently of T phage lysozyme homology domain. Kibardin AV, et al. J Mol Biol, 2003 Feb 14. PMID 12559914

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFkappaB inflammatory axis in coronary artery disease.
    Title: Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFκB inflammatory axis in coronary artery disease.
  2. Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life.
    Title: Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice.
  3. Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice
    Title: Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.
  4. Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism.
    Title: Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo.
  5. Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis
    Title: Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses.
  6. role in regulation of the enteric host-microbe homeostasis
    Title: Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.
  7. The authors demonstrate that PGLYRP-2 and Nod2 are both required for arthritis in the peptidoglycan-induced arthritis model in mice.
    Title: PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.
  8. substantially impaired Listeria monocytogenes invasion and early intracellular growth in human epithelial cells. [TagL]
    Title: Mammalian peptidoglycan recognition protein TagL inhibits Listeria monocytogenes invasion into epithelial cells.
  9. In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi.
    Title: Innate immune responses in peptidoglycan recognition protein L-deficient mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidoglycan immune receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan immune receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biological process involved in interaction with host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
peptidoglycan recognition protein long
NP_001258405.1
NP_001258406.1
NP_001258407.1
NP_001258408.1
NP_067294.2
XP_006524773.1
XP_006524774.1
XP_006524775.1
XP_006524776.1
XP_006524777.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271476.1 → NP_001258405.1  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See identical proteins and their annotated locations for NP_001258405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK039953, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8K4I8, Q8VCS0, Q9QXZ1, Q9QXZ2
    UniProtKB/TrEMBL
    Q54A77
    Related
    ENSMUSP00000158365.2, ENSMUST00000236386.2
    Conserved Domains (1) summary
    smart00701
    Location:360 → 505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  2. NM_001271477.1 → NP_001258406.1  N-acetylmuramoyl-L-alanine amidase isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK050019, CT485616
    Consensus CDS
    CCDS89066.1
    UniProtKB/TrEMBL
    A0A498WFR9
    Related
    ENSMUSP00000110099.3, ENSMUST00000114455.3
    Conserved Domains (1) summary
    cl02712
    Location:360 → 421
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

  3. NM_001271478.1 → NP_001258407.1  N-acetylmuramoyl-L-alanine amidase isoform c precursor

    See identical proteins and their annotated locations for NP_001258407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c, also known as TagL-epsilon) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK039953, AY282722, CT485616
    Consensus CDS
    CCDS89065.1
    UniProtKB/TrEMBL
    Q71S36
    Related
    ENSMUSP00000157771.2, ENSMUST00000237130.2
    Conserved Domains (1) summary
    cl02712
    Location:360 → 427
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

  4. NM_001271479.1 → NP_001258408.1  N-acetylmuramoyl-L-alanine amidase isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d, also known as TagL-delta) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AY282722, CT485616
    Consensus CDS
    CCDS89067.1
    UniProtKB/TrEMBL
    A0A494B9M1, Q71S45
    Related
    ENSMUSP00000157711.2, ENSMUST00000237165.2

  5. NM_021319.5 → NP_067294.2  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See identical proteins and their annotated locations for NP_067294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK050019, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8K4I8, Q8VCS0, Q9QXZ1, Q9QXZ2
    UniProtKB/TrEMBL
    Q54A77
    Related
    ENSMUSP00000129964.2, ENSMUST00000170392.9
    Conserved Domains (1) summary
    smart00701
    Location:360 → 505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

RNA

  1. NR_073184.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY282722, CT485616

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32631433..32643157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524714.4 → XP_006524777.1  N-acetylmuramoyl-L-alanine amidase isoform X3

    See identical proteins and their annotated locations for XP_006524777.1

    UniProtKB/TrEMBL
    Q71S36
    Conserved Domains (1) summary
    cl02712
    Location:360 → 427
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

  2. XM_006524713.4 → XP_006524776.1  N-acetylmuramoyl-L-alanine amidase isoform X2

    Conserved Domains (1) summary
    cl02712
    Location:360 → 421
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

  3. XM_006524712.4 → XP_006524775.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524775.1

    UniProtKB/TrEMBL
    Q54A77
    Conserved Domains (1) summary
    smart00701
    Location:360 → 505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  4. XM_006524711.4 → XP_006524774.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524774.1

    UniProtKB/TrEMBL
    Q54A77
    Conserved Domains (1) summary
    smart00701
    Location:360 → 505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

  5. XM_006524710.4 → XP_006524773.1  N-acetylmuramoyl-L-alanine amidase isoform X1

    See identical proteins and their annotated locations for XP_006524773.1

    UniProtKB/TrEMBL
    Q54A77
    Conserved Domains (1) summary
    smart00701
    Location:360 → 505
    PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCS0.1 GenPept UniProtKB/Swiss-Prot:Q8VCS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous