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Zfp112 zinc finger protein 112 [ Mus musculus (house mouse) ]

Gene ID: 57745, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp112provided by MGI
Official Full Name
zinc finger protein 112provided by MGI
Primary source
MGI:MGI:1929115
See related
Ensembl:ENSMUSG00000052675 AllianceGenome:MGI:1929115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf112; Znf228
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder and ureter. Orthologous to human ZNF112 (zinc finger protein 112). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 1.6), frontal lobe adult (RPKM 1.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 10.27 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23811348..23827254)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24112320..24127952)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36694 Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 180 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235 Neighboring gene STARR-seq mESC enhancer starr_18251 Neighboring gene zinc finger protein 114

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 112
Names
zfp-112
zinc finger protein 112 homolog
zinc finger protein 112; zinc finger protein ZFP112

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420121.1 → NP_001407050.1  zinc finger protein 112 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138791
    UniProtKB/TrEMBL
    A0A1L1SUE1

  2. NM_001420122.1 → NP_001407051.1  zinc finger protein 112 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138791

  3. NM_001420123.1 → NP_001407052.1  zinc finger protein 112 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138791

  4. NM_001420124.1 → NP_001407053.1  zinc finger protein 112 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138791

  5. NM_001420125.1 → NP_001407054.1  zinc finger protein 112 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138791

  6. NM_021307.3 → NP_067282.2  zinc finger protein 112 isoform 1

    See identical proteins and their annotated locations for NP_067282.2

    Status: VALIDATED

    Source sequence(s)
    AC138791
    Consensus CDS
    CCDS39824.1
    UniProtKB/Swiss-Prot
    D3Z7D1, E9QP25, Q0VAW7, Q9R163
    Related
    ENSMUSP00000005413.4, ENSMUST00000005413.4
    Conserved Domains (5) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:258 → 712
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553 → 573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:621 → 645
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    23811348..23827254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153283.1 → XP_036009176.1  zinc finger protein 112 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:251 → 716
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557 → 577
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VAW7.2 GenPept UniProtKB/Swiss-Prot:Q0VAW7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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