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Noc2l NOC2 like nucleolar associated transcriptional repressor [ Mus musculus (house mouse) ]

Gene ID: 57741, updated on 21-Apr-2024

Summary

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Official Symbol
Noc2lprovided by MGI
Official Full Name
NOC2 like nucleolar associated transcriptional repressorprovided by MGI
Primary source
MGI:MGI:1931051
See related
Ensembl:ENSMUSG00000095567 AllianceGenome:MGI:1931051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NIR
Summary
Predicted to enable several functions, including nucleosomal histone binding activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including chromatin assembly; negative regulation of apoptotic process; and negative regulation of nitrogen compound metabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including connective tissue; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 56.2), thymus adult (RPKM 50.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4; 4 E2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156319112..156332078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156234655..156247616)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family N member 1 Neighboring gene kelch-like 17 Neighboring gene microRNA 7658 Neighboring gene STARR-seq mESC enhancer starr_12292 Neighboring gene predicted gene, 52691 Neighboring gene sterile alpha motif domain containing 11 Neighboring gene predicted gene, 47252 Neighboring gene predicted gene, 54274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel INHAT repressor (NIR) is required for early lymphocyte development. Ma CA, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201955, Free PMC Article
  2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Hublitz P, et al. Genes Dev, 2005 Dec 1. PMID 16322561, Free PMC Article
  3. The histone acetyltransferase inhibitor Nir regulates epidermis development. Duteil D, et al. Development, 2018 Mar 21. PMID 29490983
  4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data define Nir as a key regulator of skin development.
    Title: The histone acetyltransferase inhibitor Nir regulates epidermis development.
  2. results show that NIR cooperate with p53 to impose checkpoint for the generation of mature B and T lymphocytes.
    Title: Novel INHAT repressor (NIR) is required for early lymphocyte development.
  3. Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes
    Title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Noc1p-Noc2p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Noc2p-Noc3p complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleolar complex protein 2 homolog
Names
NOC2-like protein
novel INHAT repressor
nucleolar complex associated 2 homolog
protein NOC2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369270.2 → NP_001356199.1  nucleolar complex protein 2 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806
    UniProtKB/TrEMBL
    Q8BHX6
    Conserved Domains (1) summary
    pfam03715
    Location:174 → 469
    Noc2; Noc2p family

  2. NM_001424984.1 → NP_001411913.1  nucleolar complex protein 2 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806
    UniProtKB/TrEMBL
    Q8BHX6

  3. NM_001424985.1 → NP_001411914.1  nucleolar complex protein 2 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806
    UniProtKB/TrEMBL
    Q8BHX6

  4. NM_001424986.1 → NP_001411915.1  nucleolar complex protein 2 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806

  5. NM_021303.3 → NP_067278.2  nucleolar complex protein 2 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806
    Consensus CDS
    CCDS57322.1
    UniProtKB/Swiss-Prot
    Q8VE16, Q9WV70
    UniProtKB/TrEMBL
    J3QK52
    Related
    ENSMUSP00000137253.2, ENSMUST00000179543.8
    Conserved Domains (1) summary
    pfam03715
    Location:331 → 626
    Noc2; Noc2p family

RNA

  1. NR_161236.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CAAA01066805, CAAA01066806

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156319112..156332078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253688.1 → XP_030109548.1  nucleolar complex protein 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8VE16, Q9WV70
    Conserved Domains (1) summary
    pfam03715
    Location:358 → 653
    Noc2; Noc2p family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV70.2 GenPept UniProtKB/Swiss-Prot:Q9WV70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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