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Stk32c serine/threonine kinase 32C [ Mus musculus (house mouse) ]

Gene ID: 57740, updated on 11-Apr-2024

Summary

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Official Symbol
Stk32cprovided by MGI
Official Full Name
serine/threonine kinase 32Cprovided by MGI
Primary source
MGI:MGI:2385336
See related
Ensembl:ENSMUSG00000015981 AllianceGenome:MGI:2385336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKE; Pkek; YANK3
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in brain; gonad; large intestine; metanephros; and skin. Orthologous to human STK32C (serine/threonine kinase 32C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 32.1), frontal lobe adult (RPKM 29.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F4; 7 84.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138683554..138793223, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139103638..139213307, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene janus kinase and microtubule interacting protein 3 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:146410713-146410866 Neighboring gene leucine rich repeat containing 27 Neighboring gene predicted gene, 32315 Neighboring gene PWWP domain containing 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 32C
Names
PKE protein kinase
NP_001156012.1
NP_001407042.1
NP_001407043.1
NP_067277.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162540.1 → NP_001156012.1  serine/threonine-protein kinase 32C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB041542, AC093363, AC174642, AK046439
    Consensus CDS
    CCDS52425.1
    UniProtKB/TrEMBL
    E9PXK4
    Related
    ENSMUSP00000126638.2, ENSMUST00000165870.2
    Conserved Domains (2) summary
    COG0515
    Location:2 → 336
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd05578
    Location:1 → 234
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  2. NM_001420113.1 → NP_001407042.1  serine/threonine-protein kinase 32C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC174642

  3. NM_001420114.1 → NP_001407043.1  serine/threonine-protein kinase 32C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC174642

  4. NM_021302.4 → NP_067277.2  serine/threonine-protein kinase 32C isoform 1

    See identical proteins and their annotated locations for NP_067277.2

    Status: VALIDATED

    Source sequence(s)
    AC174642
    Consensus CDS
    CCDS21952.1
    UniProtKB/Swiss-Prot
    Q8QZV4, Q9JJG4
    Related
    ENSMUSP00000016125.6, ENSMUST00000016125.12
    Conserved Domains (2) summary
    smart00220
    Location:94 → 349
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:93 → 352
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    138683554..138793223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZV4.1 GenPept UniProtKB/Swiss-Prot:Q8QZV4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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