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ZNF317 zinc finger protein 317 [ Homo sapiens (human) ]

Gene ID: 57693, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF317provided by HGNC
Official Full Name
zinc finger protein 317provided by HGNC
Primary source
HGNC:HGNC:13507
See related
Ensembl:ENSG00000130803 MIM:613864; AllianceGenome:HGNC:13507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 11.1), lymph node (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9140397..9163413)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9266590..9289607)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9251073..9274089)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily G member 15 pseudogene Neighboring gene olfactory receptor family 7 subfamily G member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9270512-9271012 Neighboring gene olfactory receptor family 7 subfamily D member 2 Neighboring gene elongin C pseudogene 29 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9300121-9300643 Neighboring gene olfactory receptor family 7 subfamily E member 16 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms. Takashima H, et al. Biochem Biophys Res Commun, 2001 Nov 9. PMID 11688974
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877
  3. Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Xia YK, et al. Protein Cell, 2021 Jul. PMID 32683582, Free PMC Article
  4. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  5. An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Zhang Y, et al. Cell Chem Biol, 2022 Jan 20. PMID 34672954, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular cloning and characterization of isoforms
    Title: Molecular cloning and characterization of a KRAB-containing zinc finger protein, ZNF317, and its isoforms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 317
Names
KRAB-containing zinc finger protein 317

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190791.2 → NP_001177720.1  zinc finger protein 317 isoform 2

    See identical proteins and their annotated locations for NP_001177720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting protein (isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AF148135, BC009367, DA757943
    Consensus CDS
    CCDS54213.1
    Related
    ENSP00000353554.2, ENST00000360385.7
    Conserved Domains (5) summary
    smart00349
    Location:57 → 103
    KRAB; krueppel associated box
    COG5048
    Location:190 → 548
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472 → 492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:57 → 96
    KRAB; KRAB box
    pfam13465
    Location:485 → 508
    zf-H2C2_2; Zinc-finger double domain

  2. NM_020933.5 → NP_065984.3  zinc finger protein 317 isoform 1

    See identical proteins and their annotated locations for NP_065984.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC078154, DA757943
    Consensus CDS
    CCDS12210.1
    UniProtKB/Swiss-Prot
    Q6DCA9, Q96PM0, Q96PM1, Q96PQ6, Q96PT2, Q9HCI4
    Related
    ENSP00000247956.5, ENST00000247956.11
    Conserved Domains (3) summary
    smart00349
    Location:57 → 109
    KRAB; krueppel associated box
    COG5048
    Location:222 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:504 → 524
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_102435.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011464, BC009367
    Related
    ENST00000591278.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9140397..9163413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439139.1 → XP_047295095.1  zinc finger protein 317 isoform X1

RNA

  1. XR_430146.5 RNA Sequence

  2. XR_007066921.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9266590..9289607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321568.1 → XP_054177543.1  zinc finger protein 317 isoform X1

RNA

  1. XR_008485171.1 RNA Sequence

  2. XR_008485172.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PQ6.2 GenPept UniProtKB/Swiss-Prot:Q96PQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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