U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NHSL3 NHS like 3 [ Homo sapiens (human) ]

Gene ID: 57648, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
NHSL3provided by HGNC
Official Full Name
NHS like 3provided by HGNC
Primary source
HGNC:HGNC:29301
See related
Ensembl:ENSG00000162522 AllianceGenome:HGNC:29301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1522
Summary
Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 27.9), duodenum (RPKM 23.6) and 20 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NHSL3 in Genome Data Viewer
Location:
1p35.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32741830..32774970)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32601643..32634754)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33207431..33240571)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 694 Neighboring gene zinc finger and BTB domain containing 8 opposite strand Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33107487-33108246 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33108247-33109005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 695 Neighboring gene hESC enhancers GRCh37_chr1:33116021-33116608 and GRCh37_chr1:33116609-33117197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 696 Neighboring gene RB binding protein 4, chromatin remodeling factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33154443-33154943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33160284-33161022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33167839-33168604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33168605-33169370 Neighboring gene syncoilin, intermediate filament protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 607 Neighboring gene Sharpr-MPRA regulatory region 2185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33183271-33184026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33189892-33190720 Neighboring gene Sharpr-MPRA regulatory region 8469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33200787-33201312 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33201837-33202361 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33202362-33202885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33219766-33220279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33225004-33225886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33225887-33226770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33227405-33227625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33231243-33232135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33232136-33233029 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33235076-33235991 Neighboring gene Sharpr-MPRA regulatory region 15696 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6796 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:33251929-33253128 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 697 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33269619-33270293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33270294-33270967 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33275934-33276570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33276571-33277206 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33282071-33282572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33282573-33283072 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 701 Neighboring gene S100P binding protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6850 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33333351-33333852 Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. Wang B, et al. J Exp Clin Cancer Res, 2020 Aug 27. PMID 32854746, Free PMC Article
  2. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer. Liu YZ, et al. Sci Rep, 2016 Apr 21. PMID 27098511, Free PMC Article
  3. miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522. Li Y, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30177391
  4. HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm. Ou M, et al. ESC Heart Fail, 2022 Oct. PMID 35730141, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Apr 28. PMID 10819331

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm.
    Title: HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm.
  2. KIAA1522 potentiates TNFalpha-NFkappaB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
    Title: KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma.
  3. miR-125b-5p functions as a tumor suppressor and regulates breast cancer cell progression through targeting KIAA1522
    Title: miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522.
  4. high expression of KIAA1522 can be used as an independent biomarker for predication of poor survival and platinum-resistance of NSCLC patients, and aberrant KIAA1522 might be a new target for the therapy of the disease.
    Title: KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NHS-like protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198972.2 → NP_001185901.1  NHS-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001185901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB040955, AC114489, AK298965, BC004879
    Consensus CDS
    CCDS55588.1
    UniProtKB/Swiss-Prot
    B4DQU8, B5MDY0, C9JH84, Q8TCQ0, Q9P206
    Related
    ENSP00000362579.1, ENST00000373480.1
    Conserved Domains (1) summary
    PHA03247
    Location:724 → 1000
    PHA03247; large tegument protein UL36; Provisional

  2. NM_001198973.2 → NP_001185902.1  NHS-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001185902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon and lacks two consecutive in-frame coding exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AB040955, AC114489, AK298965
    Consensus CDS
    CCDS55589.1
    UniProtKB/Swiss-Prot
    Q9P206
    Related
    ENSP00000294521.3, ENST00000294521.7

  3. NM_001369553.1 → NP_001356482.1  NHS-like protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114489
    Consensus CDS
    CCDS90910.1
    Related
    ENSP00000362580.3, ENST00000373481.7
    Conserved Domains (1) summary
    PHA03247
    Location:735 → 1011
    PHA03247; large tegument protein UL36; Provisional

  4. NM_020888.3 → NP_065939.2  NHS-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_065939.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB040955, AC114489, AI587184, AL713671
    Consensus CDS
    CCDS41298.1
    UniProtKB/Swiss-Prot
    Q9P206
    Related
    ENSP00000383851.2, ENST00000401073.7
    Conserved Domains (1) summary
    PHA03247
    Location:783 → 1059
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32741830..32774970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32601643..32634754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P206.2 GenPept UniProtKB/Swiss-Prot:Q9P206

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous