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TMEM181 transmembrane protein 181 [ Homo sapiens (human) ]

Gene ID: 57583, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM181provided by HGNC
Official Full Name
transmembrane protein 181provided by HGNC
Primary source
HGNC:HGNC:20958
See related
Ensembl:ENSG00000146433 MIM:613209; AllianceGenome:HGNC:20958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR178; KIAA1423
Summary
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Expression
Ubiquitous expression in stomach (RPKM 9.9), testis (RPKM 9.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TMEM181 in Genome Data Viewer
Location:
6q25.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (158536640..158635429)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (159781619..159880620)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (158957672..159056461)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TUB like protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25355 Neighboring gene RNA, 7SL, cytoplasmic 173, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:158884819-158885810 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:158885811-158886802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158890813-158891694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158895792-158896364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158900383-158900884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158927517-158928017 Neighboring gene Sharpr-MPRA regulatory region 4140 Neighboring gene Sharpr-MPRA regulatory region 10808 Neighboring gene calcyclin binding protein pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158982655-158983154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158982153-158982654 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159000120-159000332 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:159030351-159030852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159051575-159052076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:159052077-159052576 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159053255-159053416 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159065146-159066089 Neighboring gene microRNA 7161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17742 Neighboring gene dynein light chain Tctex-type 1 Neighboring gene MPRA-validated peak6273 silencer Neighboring gene synaptotagmin like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159128779-159129410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159129411-159130042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25360 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:159141094-159142293 Neighboring gene AMZ2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TMEM181: a key mediator of cytolethal distending toxin required for Wnt signaling activity. Zhang J, et al. J Genet Genomics, 2023 Jan. PMID 35577237
  2. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. Wistrand M, et al. Protein Sci, 2006 Mar. PMID 16452613, Free PMC Article
  3. Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Wollscheid B, et al. Nat Biotechnol, 2009 Apr. PMID 19349973, Free PMC Article
  4. Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A. Hoel CM, et al. Elife, 2022 Nov 14. PMID 36373655, Free PMC Article
  5. Haploid genetic screens in human cells identify host factors used by pathogens. Carette JE, et al. Science, 2009 Nov 27. PMID 19965467

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 181 (TMEM181) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables toxic substance binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables toxic substance binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 181
Names
G protein-coupled receptor 178

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376817.1 → NP_001363746.1  transmembrane protein 181 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL591025
    UniProtKB/TrEMBL
    Q8N4V6
    Conserved Domains (1) summary
    pfam06664
    Location:177 → 472
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. NM_001376850.1 → NP_001363779.1  transmembrane protein 181 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591025
    UniProtKB/TrEMBL
    Q8N4V6
    Conserved Domains (1) summary
    pfam06664
    Location:136 → 431
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  3. NM_001376852.1 → NP_001363781.1  transmembrane protein 181 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Consensus CDS
    CCDS94026.1
    UniProtKB/Swiss-Prot
    A0A804HII6, Q5VTU1, Q9P2C4
    UniProtKB/TrEMBL
    Q8N4V6
    Related
    ENSP00000507085.1, ENST00000684151.1
    Conserved Domains (1) summary
    pfam06664
    Location:128 → 423
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  4. NM_001376854.1 → NP_001363783.1  transmembrane protein 181 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:128 → 396
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  5. NM_001376855.1 → NP_001363784.1  transmembrane protein 181 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591025
    UniProtKB/TrEMBL
    Q8N4V6
    Conserved Domains (1) summary
    pfam06664
    Location:96 → 391
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  6. NM_001376856.1 → NP_001363785.1  transmembrane protein 181 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:47 → 342
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  7. NM_020823.2 → NP_065874.2  transmembrane protein 181 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Consensus CDS
    CCDS43520.2
    UniProtKB/TrEMBL
    Q8N4V6
    Related
    ENSP00000356057.4, ENST00000367090.4
    Conserved Domains (1) summary
    pfam06664
    Location:170 → 464
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RNA

  1. NR_164859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591025

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    158536640..158635429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536000.2 → XP_011534302.2  transmembrane protein 181 isoform X1

  2. XM_011536003.3 → XP_011534305.2  transmembrane protein 181 isoform X5

  3. XM_047419182.1 → XP_047275138.1  transmembrane protein 181 isoform X6

  4. XM_047419183.1 → XP_047275139.1  transmembrane protein 181 isoform X7

  5. XM_047419185.1 → XP_047275141.1  transmembrane protein 181 isoform X9

  6. XM_047419187.1 → XP_047275143.1  transmembrane protein 181 isoform X10

  7. XM_011536001.3 → XP_011534303.1  transmembrane protein 181 isoform X3

    UniProtKB/TrEMBL
    Q8N4V6
    Conserved Domains (1) summary
    pfam06664
    Location:154 → 449
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  8. XM_011536002.3 → XP_011534304.1  transmembrane protein 181 isoform X4

    UniProtKB/TrEMBL
    Q8N4V6
    Conserved Domains (1) summary
    pfam06664
    Location:146 → 441
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  9. XM_047419184.1 → XP_047275140.1  transmembrane protein 181 isoform X8

  10. XM_047419181.1 → XP_047275137.1  transmembrane protein 181 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    159781619..159880620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356096.1 → XP_054212071.1  transmembrane protein 181 isoform X1

  2. XM_054356100.1 → XP_054212075.1  transmembrane protein 181 isoform X5

  3. XM_054356101.1 → XP_054212076.1  transmembrane protein 181 isoform X6

  4. XM_054356102.1 → XP_054212077.1  transmembrane protein 181 isoform X7

  5. XM_054356104.1 → XP_054212079.1  transmembrane protein 181 isoform X9

  6. XM_054356105.1 → XP_054212080.1  transmembrane protein 181 isoform X10

  7. XM_054356099.1 → XP_054212074.1  transmembrane protein 181 isoform X4

  8. XM_054356103.1 → XP_054212078.1  transmembrane protein 181 isoform X8

  9. XM_054356098.1 → XP_054212073.1  transmembrane protein 181 isoform X3

  10. XM_054356097.1 → XP_054212072.1  transmembrane protein 181 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P2C4.3 GenPept UniProtKB/Swiss-Prot:Q9P2C4

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