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REXO1 RNA exonuclease 1 homolog [ Homo sapiens (human) ]

Gene ID: 57455, updated on 5-Mar-2024

Summary

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Official Symbol
REXO1provided by HGNC
Official Full Name
RNA exonuclease 1 homologprovided by HGNC
Primary source
HGNC:HGNC:24616
See related
Ensembl:ENSG00000079313 MIM:609614; AllianceGenome:HGNC:24616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REX1; ELOABP1; EloA-BP1; TCEB3BP1
Summary
Predicted to enable exonuclease activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 12.3), spleen (RPKM 7.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1815248..1848483, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1786564..1819798, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1815247..1848482, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1789295-1790117 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1795609-1796421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1796422-1797233 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1799861-1800031 Neighboring gene MPRA-validated peak3225 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1811783-1812528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13626 Neighboring gene uncharacterized LOC100288123 Neighboring gene microRNA 1909 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1827207-1827342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1828468-1828968 Neighboring gene MPRA-validated peak3226 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1834459-1835425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1835426-1836391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1837058-1838052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1853940-1854496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1854497-1855054 Neighboring gene Sharpr-MPRA regulatory region 8340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1861121-1862006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9749 Neighboring gene KLF16 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9751 Neighboring gene KLF transcription factor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1865114-1865668 Neighboring gene KLF16-I enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1873541-1874256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1875445-1876145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1876146-1876845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1876846-1877546 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1884760-1884907 Neighboring gene abhydrolase domain containing 17A, depalmitoylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Demarcation of stable subpopulations within the pluripotent hESC compartment. Bhatia S, et al. PLoS One, 2013. PMID 23437358, Free PMC Article
  2. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. Bhandari DR, et al. PLoS One, 2010 May 5. PMID 20463961, Free PMC Article
  3. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. Gontan C, et al. Nature, 2012 Apr 29. PMID 22596162
  4. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. Tamura K, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943681
  5. Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity. Wang Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33298525, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of REX1 expression demarcates stable, OCT4-positive lineage pluripotent human embryonic stem cells.
    Title: Demarcation of stable subpopulations within the pluripotent hESC compartment.
  2. These findings showed that REX1 regulates the proliferation/differentiation of human mesenchymal stem cells through the suppression of p38 MAPK signaling via the direct suppression of MKK3.
    Title: REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells.
  3. cloning and characterization of a novel human exonuclease domain-containing protein, Elongin A-binding protein 1; it is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII
    Title: Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA exonuclease 1 homolog
Names
REX1, RNA exonuclease 1 homolog
elongin-A-binding protein 1
transcription elongation factor B polypeptide 3-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020695.4 → NP_065746.3  RNA exonuclease 1 homolog

    See identical proteins and their annotated locations for NP_065746.3

    Status: VALIDATED

    Source sequence(s)
    AC012615, BC032244
    Consensus CDS
    CCDS32866.1
    UniProtKB/Swiss-Prot
    Q8N1G1, Q9ULT2
    Related
    ENSP00000170168.3, ENST00000170168.9
    Conserved Domains (2) summary
    cd06145
    Location:1061 → 1209
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:802 → 962
    EloA-BP1; ElonginA binding-protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1815248..1848483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027028.2 → XP_016882517.1  RNA exonuclease 1 homolog isoform X2

  2. XM_017027029.2 → XP_016882518.1  RNA exonuclease 1 homolog isoform X4

  3. XM_011528144.2 → XP_011526446.1  RNA exonuclease 1 homolog isoform X1

    Conserved Domains (2) summary
    cd06145
    Location:1070 → 1203
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:802 → 962
    EloA-BP1; ElonginA binding-protein 1

  4. XM_011528146.3 → XP_011526448.1  RNA exonuclease 1 homolog isoform X3

    Conserved Domains (2) summary
    cd06145
    Location:1035 → 1168
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    pfam15870
    Location:767 → 927
    EloA-BP1; ElonginA binding-protein 1

  5. XM_047439121.1 → XP_047295077.1  RNA exonuclease 1 homolog isoform X6

  6. XM_047439120.1 → XP_047295076.1  RNA exonuclease 1 homolog isoform X5

  7. XM_047439122.1 → XP_047295078.1  RNA exonuclease 1 homolog isoform X7

  8. XM_047439123.1 → XP_047295079.1  RNA exonuclease 1 homolog isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1786564..1819798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321525.1 → XP_054177500.1  RNA exonuclease 1 homolog isoform X2

  2. XM_054321527.1 → XP_054177502.1  RNA exonuclease 1 homolog isoform X4

  3. XM_054321524.1 → XP_054177499.1  RNA exonuclease 1 homolog isoform X1

  4. XM_054321526.1 → XP_054177501.1  RNA exonuclease 1 homolog isoform X3

  5. XM_054321529.1 → XP_054177504.1  RNA exonuclease 1 homolog isoform X6

  6. XM_054321528.1 → XP_054177503.1  RNA exonuclease 1 homolog isoform X5

  7. XM_054321530.1 → XP_054177505.1  RNA exonuclease 1 homolog isoform X7

  8. XM_054321531.1 → XP_054177506.1  RNA exonuclease 1 homolog isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1G1.3 GenPept UniProtKB/Swiss-Prot:Q8N1G1

Gene LinkOut

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