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NDRG3 NDRG family member 3 [ Homo sapiens (human) ]

Gene ID: 57446, updated on 3-Apr-2024

Summary

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Official Symbol
NDRG3provided by HGNC
Official Full Name
NDRG family member 3provided by HGNC
Primary source
HGNC:HGNC:14462
See related
Ensembl:ENSG00000101079 MIM:605273; AllianceGenome:HGNC:14462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in signal transduction. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 38.0), prostate (RPKM 20.1) and 23 other tissues See more
Orthologs
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Genomic context

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See NDRG3 in Genome Data Viewer
Location:
20q11.23
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (36651771..36746090, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (38376108..38470363, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35280174..35374493, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12876 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:35235327-35236526 Neighboring gene RAB5 interacting factor Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35261429-35261930 Neighboring gene Src like adaptor 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:35271232-35271902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:35305009-35305810 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:35324917-35325417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35373956-35374922 Neighboring gene MPRA-validated peak4204 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35393973-35394472 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:35399249-35399414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:35401925-35402470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35402471-35403017 Neighboring gene uncharacterized LOC124904894 Neighboring gene DSN1 component of MIS12 kinetochore complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia. Wang X, et al. Oncol Rep, 2023 Aug. PMID 37350410, Free PMC Article
  2. High expression of NDRG3 correlates with poor prognosis in gastric cancer patients. Liu Y, et al. Rev Esp Enferm Dig, 2021 Jul. PMID 33562989
  3. Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein. Kim KR, et al. Biomolecules, 2020 Jan 6. PMID 31935861, Free PMC Article
  4. NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma. Jing JS, et al. Biosci Rep, 2018 Dec 21. PMID 30413609, Free PMC Article
  5. NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors. Lee GY, et al. Exp Mol Med, 2018 May 14. PMID 29760417, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
    Title: Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
  2. NDRG3 regulates imatinib resistance by promoting beta-catenin accumulation in the nucleus in chronic myelogenous leukemia.
    Title: NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia.
  3. The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells.
    Title: The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells.
  4. High expression of NDRG3 correlates with poor prognosis in gastric cancer patients.
    Title: High expression of NDRG3 correlates with poor prognosis in gastric cancer patients.
  5. Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein.
    Title: Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein.
  6. high NDRG3 expression facilitates HCC metastasis via regulating the turnover of beta-catenin, as well as provides a potential therapeutic target for future therapeutic interventions
    Title: High NDRG3 expression facilitates HCC metastasis by promoting nuclear translocation of β-catenin.
  7. The results revealed that compared with non-tumor tissues, hepatocellular carcinoma tissues showed significantly higher NDRG3 expression.
    Title: NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma.
  8. NDRG3 may have an anti-metastatic function in prostate cancer under a hypoxic microenvironment.
    Title: NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors.
  9. The IHC data demonstrated that the NDRG3 expression was significantly correlated with pathological grade (p= 0.038), N (p= 0.020) and TNM stage (p= 0.002) in non-small cell lung cancer.
    Title: High expression of NDRG3 associates with unfavorable overall survival in non-small cell lung cancer.
  10. increased NDRG3 expression is associated with hepatocellular carcinoma and drug resistance.
    Title: MicroRNA31-NDRG3 regulation axes are essential for hepatocellular carcinoma survival and drug resistance.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NDRG family member 3 (NDRG3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
protein NDRG3
Names
N-myc downstream-regulated gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022477.4 → NP_071922.2  protein NDRG3 isoform b

    See identical proteins and their annotated locations for NP_071922.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) that is shorter compared to isoform a.
    Source sequence(s)
    AA903471, AF308609, AK023618, AL132768, BC136489
    Consensus CDS
    CCDS13284.1
    UniProtKB/Swiss-Prot
    Q9UGV2
    Related
    ENSP00000352703.2, ENST00000359675.6
    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  2. NM_032013.4 → NP_114402.1  protein NDRG3 isoform a

    See identical proteins and their annotated locations for NP_114402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA903471, AB044943, AF308609, AL132768
    Consensus CDS
    CCDS13285.1
    UniProtKB/Swiss-Prot
    A2A2S8, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6, Q9UGV2
    Related
    ENSP00000345292.1, ENST00000349004.6
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

RNA

  1. NR_038370.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA903471, AF308609, AK295420, AL132768, BC136489

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    36651771..36746090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528927.4 → XP_011527229.1  protein NDRG3 isoform X5

    See identical proteins and their annotated locations for XP_011527229.1

    Conserved Domains (1) summary
    pfam03096
    Location:20 → 305
    Ndr; Ndr family

  2. XM_011528928.4 → XP_011527230.1  protein NDRG3 isoform X8

    UniProtKB/TrEMBL
    B7Z323
    Related
    ENSP00000362878.3, ENST00000373773.7
    Conserved Domains (2) summary
    COG0596
    Location:19 → 220
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:6 → 225
    Abhydrolase; alpha/beta hydrolases

  3. XM_006723837.5 → XP_006723900.1  protein NDRG3 isoform X3

    See identical proteins and their annotated locations for XP_006723900.1

    UniProtKB/TrEMBL
    Q5TH30
    Related
    ENSP00000362909.2, ENST00000373803.6
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  4. XM_017027979.2 → XP_016883468.1  protein NDRG3 isoform X6

    UniProtKB/Swiss-Prot
    A2A2S8, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6, Q9UGV2
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  5. XM_017027978.3 → XP_016883467.1  protein NDRG3 isoform X3

    UniProtKB/TrEMBL
    Q5TH30
    Conserved Domains (1) summary
    pfam03096
    Location:32 → 317
    Ndr; Ndr family

  6. XM_017027980.3 → XP_016883469.1  protein NDRG3 isoform X7

  7. XM_006723838.5 → XP_006723901.1  protein NDRG3 isoform X4

    Conserved Domains (2) summary
    COG0596
    Location:29 → 303
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:23 → 308
    Ndr; Ndr family

  8. XM_011528926.3 → XP_011527228.1  protein NDRG3 isoform X2

    UniProtKB/TrEMBL
    F8WBF9
    Conserved Domains (2) summary
    COG0596
    Location:8 → 282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:2 → 287
    Ndr; Ndr family

  9. XM_011528925.4 → XP_011527227.1  protein NDRG3 isoform X1

    Conserved Domains (2) summary
    COG0596
    Location:8 → 282
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam03096
    Location:2 → 287
    Ndr; Ndr family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    38376108..38470363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323763.1 → XP_054179738.1  protein NDRG3 isoform X5

  2. XM_054323766.1 → XP_054179741.1  protein NDRG3 isoform X8

  3. XM_054323760.1 → XP_054179735.1  protein NDRG3 isoform X3

    UniProtKB/TrEMBL
    Q5TH30

  4. XM_054323764.1 → XP_054179739.1  protein NDRG3 isoform X6

    UniProtKB/Swiss-Prot
    A2A2S8, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6, Q9UGV2

  5. XM_054323761.1 → XP_054179736.1  protein NDRG3 isoform X3

    UniProtKB/TrEMBL
    Q5TH30

  6. XM_054323762.1 → XP_054179737.1  protein NDRG3 isoform X4

  7. XM_054323765.1 → XP_054179740.1  protein NDRG3 isoform X7

  8. XM_054323759.1 → XP_054179734.1  protein NDRG3 isoform X2

  9. XM_054323758.1 → XP_054179733.1  protein NDRG3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGV2.2 GenPept UniProtKB/Swiss-Prot:Q9UGV2

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