Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcne3provided by MGI
Official Full Name: potassium voltage-gated channel, Isk-related subfamily, gene 3provided by MGI
Primary source: MGI:MGI:1891124
See related: Ensembl:ENSMUSG00000035165 AllianceGenome:MGI:1891124
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MiRP2; 2210017H05Rik
Summary: Predicted to enable potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Involved in cellular chloride ion homeostasis; potassium ion transmembrane transport; and sodium ion transport. Is active in basolateral part of cell. Is expressed in several structures, including branchial arch; ear; forelimb bud; gut; and heart. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 22.2), testis adult (RPKM 22.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.33 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99825714..99834076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100176507..100184869)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.
Title: The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.
This study showed that Kcne3 deletion impairs muscle strength and flexibility in mice.
Title: Targeted deletion of Kcne3 impairs skeletal muscle function in mice.
The findings uncover detailed molecular mechanisms underpinning a channelopathy-linked form of atrial fibrillation and emphasize the inevitability of considering extracardiac mechanisms in genetic arrhythmia syndromes.
Title: Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.
KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation
Title: KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.
Null deletion of Kcne3 produces profound changes in the excitability of auditory neurons.
Title: Functional significance of K+ channel β-subunit KCNE3 in auditory neurons.
Kcne3 deletion is therefore arrhythmogenic by a novel mechanism in which secondary hyperaldosteronism, associated with an adrenal-specific lymphocyte infiltration, impairs ventricular repolarization.
Title: Kcne3 deletion initiates extracardiac arrhythmogenesis in mice.
Data suggest that because the abundance and subcellular localization of KCNQ1 was unchanged in kcne3(-/-) mice, the modification of biophysical properties of KCNQ1 by KCNE3 is essential for its role in intestinal and tracheal transport.
Title: Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
these data indicate that KCNE1 and KCNE3 interact directly with Kv12.2 channels to regulate channel membrane trafficking
Title: KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo.
Suggest that KCNE1 stabilizes KCNQ1 S4 segment in the resting state and slows the rate of transition to the active state, while KCNE3 stabilizes the S4 segment in the active state.
Title: KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcne3 (e-PCR), detects polymorphism
- UniSTS:525249

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular chloride ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basolateral part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: potassium voltage-gated channel subfamily E member 3

Names: minK-related peptide 2; minimum potassium ion channel-related peptide 2; potassium channel subunit beta MiRP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190869.1 → NP_001177798.1 potassium voltage-gated channel subfamily E member 3

See identical proteins and their annotated locations for NP_001177798.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815, AK132773, BY096672

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000136616.2, ENSMUST00000178946.9

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_001190870.1 → NP_001177799.1 potassium voltage-gated channel subfamily E member 3

See identical proteins and their annotated locations for NP_001177799.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000130019.3, ENSMUST00000170954.10

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_001190871.2 → NP_001177800.1 potassium voltage-gated channel subfamily E member 3

See identical proteins and their annotated locations for NP_001177800.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815, DV056972, EH094997

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000147047.2, ENSMUST00000208260.2

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_001190950.1 → NP_001177879.1 potassium voltage-gated channel subfamily E member 3

See identical proteins and their annotated locations for NP_001177879.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815, BX514261, EH094997

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000147151.2, ENSMUST00000207995.2

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_001360466.1 → NP_001347395.1 potassium voltage-gated channel subfamily E member 3

Status: VALIDATED

Description

Transcript Variant: This variant (6) represents the longest transcript. All seven variants encode the same protein.

Source sequence(s)

AC121815

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_001360467.1 → NP_001347396.1 potassium voltage-gated channel subfamily E member 3

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815, BM936467

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000136415.2, ENSMUST00000179842.3

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
NM_020574.5 → NP_065599.1 potassium voltage-gated channel subfamily E member 3

See identical proteins and their annotated locations for NP_065599.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. All seven variants encode the same protein.

Source sequence(s)

AC121815, AK008744, EH094997

Consensus CDS

CCDS21495.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Related

ENSMUSP00000039353.6, ENSMUST00000049333.13

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

99825714..99834076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508062.1 → XP_006508125.1 potassium voltage-gated channel subfamily E member 3 isoform X1

See identical proteins and their annotated locations for XP_006508125.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
XM_006508059.3 → XP_006508122.1 potassium voltage-gated channel subfamily E member 3 isoform X1

See identical proteins and their annotated locations for XP_006508122.1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel
XM_017322388.1 → XP_017177877.1 potassium voltage-gated channel subfamily E member 3 isoform X1

UniProtKB/Swiss-Prot

Q9WTW2

UniProtKB/TrEMBL

Q545H9

Conserved Domains (1) summary

pfam02060
Location:48 → 96

ISK_Channel; Slow voltage-gated potassium channel