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Tmem183a transmembrane protein 183A [ Mus musculus (house mouse) ]

Gene ID: 57439, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem183aprovided by MGI
Official Full Name
transmembrane protein 183Aprovided by MGI
Primary source
MGI:MGI:1914729
See related
Ensembl:ENSMUSG00000042305 AllianceGenome:MGI:1914729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem183; 1300007B12Rik; 1700020N19Rik
Summary
Predicted to be involved in regulation of protein stability. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to several human genes including TMEM183A (transmembrane protein 183A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 21.3), CNS E18 (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134273834..134289765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134346096..134362012, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene myogenin Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Neighboring gene predicted gene, 32267 Neighboring gene STARR-seq mESC enhancer starr_02324 Neighboring gene predicted gene, 53477 Neighboring gene STARR-seq mESC enhancer starr_02326 Neighboring gene MGAT4 family, member F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
  2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 183

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042485.1 → NP_001035950.1  transmembrane protein 183 isoform b

    See identical proteins and their annotated locations for NP_001035950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AK013009, AK152852, BY142931, CF897336
    UniProtKB/Swiss-Prot
    Q9JJB9
    UniProtKB/TrEMBL
    Q9CSF0

  2. NM_020588.2 → NP_065613.1  transmembrane protein 183 isoform a

    See identical proteins and their annotated locations for NP_065613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a).
    Source sequence(s)
    AK013009, AK152852, BY142931
    Consensus CDS
    CCDS35714.1
    UniProtKB/Swiss-Prot
    Q3THC8, Q99LK6, Q9JJB9
    Related
    ENSMUSP00000046786.5, ENSMUST00000049470.11

RNA

  1. NR_151737.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124110

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134273834..134289765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003956268.2 RNA Sequence

  2. XR_004933981.1 RNA Sequence

  3. XR_003956269.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJB9.1 GenPept UniProtKB/Swiss-Prot:Q9JJB9

Gene LinkOut

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