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Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 [ Mus musculus (house mouse) ]

Gene ID: 57431, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc4provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C4provided by MGI
Primary source
MGI:MGI:1927346
See related
Ensembl:ENSMUSG00000024963 AllianceGenome:MGI:1927346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hspf2; Mcg18
Summary
Located in mitochondrion. Orthologous to human DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 41.6), colon adult (RPKM 24.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.13 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6965279..6969954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6987911..6992591, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51400 Neighboring gene FK506 binding protein 2 Neighboring gene predicted gene, 54053 Neighboring gene vascular endothelial growth factor B Neighboring gene STARR-positive B cell enhancer ABC_E1971 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7092729-7092882 Neighboring gene predicted gene, 54052

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterisation of a new human and murine member of the DnaJ family of proteins. Silins G, et al. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473517
  2. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • 2010301J22Rik

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily C member 4
Names
DnaJ (Hsp40) homolog, subfamily C, member 4
heat shock 40kD protein 2
multiple endocrine neoplasia type 1 candidate protein 18
multiple endocrine neoplasia type 1 candidate protein number 18 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356999.1 → NP_001343928.1  dnaJ homolog subfamily C member 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC120557, AK008507
    Consensus CDS
    CCDS89329.1
    UniProtKB/TrEMBL
    K3W4M1
    Related
    ENSMUSP00000025915.7, ENSMUST00000025915.13
    Conserved Domains (1) summary
    pfam00226
    Location:53 → 115
    DnaJ; DnaJ domain

  2. NM_001357000.1 → NP_001343929.1  dnaJ homolog subfamily C member 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC120557
    Consensus CDS
    CCDS89329.1
    UniProtKB/TrEMBL
    K3W4M1
    Conserved Domains (1) summary
    pfam00226
    Location:53 → 115
    DnaJ; DnaJ domain

  3. NM_001357001.1 → NP_001343930.1  dnaJ homolog subfamily C member 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    Q6GTN1
    Conserved Domains (1) summary
    pfam00226
    Location:37 → 99
    DnaJ; DnaJ domain

  4. NM_001414717.1 → NP_001401646.1  dnaJ homolog subfamily C member 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    K3W4M1

  5. NM_001414718.1 → NP_001401647.1  dnaJ homolog subfamily C member 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    K3W4M1

  6. NM_001414719.1 → NP_001401648.1  dnaJ homolog subfamily C member 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC120557

  7. NM_001414720.1 → NP_001401649.1  dnaJ homolog subfamily C member 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC120557
    UniProtKB/TrEMBL
    Q6GTN1

  8. NM_020566.2 → NP_065591.1  dnaJ homolog subfamily C member 4 isoform c

    See identical proteins and their annotated locations for NP_065591.1

    Status: VALIDATED

    Source sequence(s)
    AC120557, AF036875
    Consensus CDS
    CCDS50374.1
    UniProtKB/Swiss-Prot
    O70278, Q9D844
    Related
    ENSMUSP00000136062.2, ENSMUST00000179118.2
    Conserved Domains (2) summary
    COG0484
    Location:35 → 99
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:37 → 99
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6965279..6969954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D844.2 GenPept UniProtKB/Swiss-Prot:Q9D844

Gene LinkOut

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